Optimization and repeatability of multipool chemical exchange saturation transfer MRI of the prostate at 3.0 T

Evans, Vincent; Torrealdea, Francisco; Rega, Marilena; Appayya, Mrishta Brizmohun; Latifoltojar, Arash; Sidhu, Harbir; Kim, Mina; Kujawa, Aaron; Punwani, Shonit; Golay, Xavier; Atkinson, David

doi:10.1002/jmri.26690

Cited by 15 publications

(24 citation statements)

References 40 publications

(94 reference statements)

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“…increased B 0 inhomogeneities and additional non‐rigid motion. ICC values were reported as 0.963 (95% confidence interval 0.852, 0.991) for conventional APT‐CEST in the breast and as 33‐38% LOA for conventional APT‐ and rNOE‐CEST in the prostate . In comparison with the values in this study (ICC = 0.902 with a 95% confidence interval of 0.888, 0.913; LOA = 16%), the reliability of dualCEST is equal or even better.…”

Section: Discussioncontrasting

confidence: 47%

“…In contrast to using only a single region of interest (e.g. a whole organ or tissue), this “fixed window” approach allowed for a larger sample size for the statistical analyses. It should be kept in mind that in doing so the following assessment results are only valid for evaluating regions of 3 × 3 × 1 voxels.…”

Section: Discussionmentioning

confidence: 99%

“…However, these marginal differences indicate that deviations due to repositioning and resulting partial volume effects are quite small. The repeatability of CEST‐MRI has so far only been evaluated in a few studies with widely varying evaluation standards and in different entities . In the brain, repeatability was only evaluated using the less informative coefficient of variation, which could not be assessed in this study as there were only two repetitions for the intra‐ and inter‐session evaluation.…”

Section: Discussionmentioning

confidence: 99%

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Optimized dualCEST‐MRI for imaging of endogenous bulk mobile proteins in the human brain

et al. 2020

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Dual-frequency irradiation chemical exchange saturation transfer (dualCEST) allows imaging of endogenous bulk mobile proteins by selectively measuring the intramolecular spin diffusion. The resulting specificity to changes in the concentration, molecular size, and folding state of mobile proteins is of particular interest as a marker for neurodegenerative diseases and cancer. Until now, application of dualCEST in clinical trials was prevented by the inherently small signal-to-noise ratio and the resulting comparatively long examination time. In this study, we present an optimized acquisition protocol allowing 3D dualCEST-MRI examinations in a clinically relevant time frame. The optimization comprised the extension of the image readout to 3D, allowing a retrospective co-registration and application of denoising strategies. In addition, cosine-modulated dual-frequency presaturation pulses were implemented with a weighted acquisition scheme of the necessary frequency offsets. The optimization resulted in a signal-to-noise ratio gain by a factor of approximately 8. In particular, the application of denoising and the motion correction were the most crucial improvement steps. In vitro experiments verified the preservation of specificity of the dualCEST signal to proteins. Good-to-excellent intra-session and good intersession repeatability was achieved, allowing reliable detection of relative signal differences of about 16% or higher. Applicability in a clinical setting was demonstrated by examining a patient with glioblastoma. The optimized acquisition protocol for dualCEST-MRI at 3 T enables selective imaging of endogenous bulk mobile proteins under clinically relevant conditions. K E Y W O R D S

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Section: Discussioncontrasting

confidence: 47%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Optimized dualCEST‐MRI for imaging of endogenous bulk mobile proteins in the human brain

et al. 2020

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“…In addition, these studies are using widely ranging evaluation methods and also investigating different entities, which is why a direct comparison has to be taken with caution. Only in the male prostate, relative LOA values evaluated in a complete ROI were reported ranging between 17 and 38% for the APT and rNOE signal 46 . In comparison to these values, the reproducibility of our protocol is equal or even better.…”

Section: Discussionmentioning

confidence: 80%

Clinical routine acquisition protocol for 3D relaxation‐compensated APT and rNOE CEST‐MRI of the human brain at 3T

Goerke

Breitling

Korzowski

et al. 2021

Magnetic Resonance in Med

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“…Four amine protons were considered for each creatine molecule. e For simulation, the concentrations were taken from references 52,53 , and exchange rate measured in vivo from rat brain. 4 Three amine protons were considered for each glutamate molecule.…”

Section: In Vivo Human Brain Mr Imagingmentioning

confidence: 99%

Evaluating the feasibility of creatine‐weighted CEST MRI in human brain at 7 T using a Z‐spectral fitting approach

et al. 2019

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The current study aims to evaluate the feasibility of creatine (Cr) chemical exchange saturation transfer (CEST)‐weighted MRI at 7 T in the human brain by optimizing the saturation pulse parameters and computing contrast using a Z‐spectral fitting approach. The Cr‐weighted (Cr‐w) CEST contrast was computed from phantoms data. Simulations were carried out to obtain the optimum saturation parameters for Cr‐w CEST with lower contribution from other brain metabolites. CEST‐w images were acquired from the brains of four human subjects at different saturation parameters. The Cr‐w CEST contrast was computed using both asymmetry analysis and Z‐spectra fitting approaches (models 1 and 2, respectively) based on Lorentzian functions. For broad magnetization transfer (MT) effect, Gaussian and Super‐Lorentzian line shapes were also evaluated. In the phantom study, the Cr‐w CEST contrast showed a linear dependence on concentration in physiological range and a nonlinear dependence on saturation parameters. The in vivo Cr‐w CEST map generated using asymmetry analysis from the brain represents mixed contrast with contribution from other metabolites as well and relayed nuclear Overhauser effect (rNOE). Simulations provided an estimate for the optimum range of saturation parameters to be used for acquiring brain CEST data. The optimum saturation parameters for Cr‐w CEST to be used for brain data were around B1rms = 1.45 μT and duration = 2 seconds. The Z‐spectral fitting approach enabled computation of individual components. This also resulted in mitigating the contribution from MT and rNOE to Cr‐w CEST contrast, which is a major source of underestimation in asymmetry analysis. The proposed modified z‐spectra fitting approach (model 2) is more stable to noise compared with model 1. Cr‐w CEST contrast obtained using fitting was 6.98 ± 0.31% in gray matter and 5.45 ± 0.16% in white matter. Optimal saturation parameters reduced the contribution from other CEST effects to Cr‐w CEST contrast, and the proposed Z‐spectral fitting approach enabled computation of individual components in Z‐spectra of the brain. Therefore, it is feasible to compute Cr‐w CEST contrast with a lower contribution from other CEST and rNOE.

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Optimization and repeatability of multipool chemical exchange saturation transfer MRI of the prostate at 3.0 T

Cited by 15 publications

References 40 publications

Optimized dualCEST‐MRI for imaging of endogenous bulk mobile proteins in the human brain

Optimized dualCEST‐MRI for imaging of endogenous bulk mobile proteins in the human brain

Clinical routine acquisition protocol for 3D relaxation‐compensated APT and rNOE CEST‐MRI of the human brain at 3T

Evaluating the feasibility of creatine‐weighted CEST MRI in human brain at 7 T using a Z‐spectral fitting approach

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