Nuclear radiation environmental monitoring has become an important issue in floor surveys. From the perspective of regional environmental nuclear radiation monitoring, it is of great practical significance to establish a scientific and reliable wireless sensor monitoring network for timely and accurately grasping nuclear radiation status and ensuring nuclear safety. In this article, we design a regional environmental nuclear radiation monitoring system based on Zigbee wireless sensor network by using Zigbee wireless technology. First, the network topology suitable for nuclear radiation environment monitoring is designed. Second, the JN5121 module is selected as the core of the Zigbee wireless sensor to build the network hardware platform. Finally, the article focuses on the receiving mechanism, data transmission, coordination between network nodes, network structure, and dynamic network management, and carries on the software development to the Zigbee wireless environment monitoring network. The system can measure the data in real time, display the dose rate of y radiation effectively, and realize the functions of remote control, field control, security alarm, and environmental monitoring. It has good promotion and application value.