Optimising Selenium for Modulation of Cancer Treatments

Evans, Stephen O; Khairuddin, Puteri Farisa; Jameson, Michael B.

doi:10.21873/anticanres.12106

Cited by 38 publications

(49 citation statements)

References 27 publications

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“…Se asserts chemopreventive activity when used at concentrations higher than optimal [29,36]. Se also is applied for cancer treatment combining with chemotherapy and radiation [47]. The utmost anticarcinogenic Se effect has been obtained when administered before or at early stage of disease development [14,40].…”

Section: Selenium and Cancermentioning

confidence: 99%

“…Se supplementation along with conventional anticancer therapies was shown to enhance the efficiency of chemotherapeutic drugs, decrease side effects and improve general condition of the patients [48][49][50]. However, more clinical trials are needed to estimate safety and efficiency of Se compounds in modulation both effectiveness and toxicity of common anticancer therapies [47]. The data obtained from already performed clinical trials are not sufficient and some of them are ambivalent.…”

Section: Selenium and Cancermentioning

confidence: 99%

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Selenium Anticancer Properties and Impact on Cellular Redox Status

et al. 2020

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(1) Background: In this review, we provide information published in recent years on the chemical forms, main biological functions and especially on antioxidant and prooxidant activities of selenium. The main focus is put on the impact of selenoproteins on maintaining cellular redox balance and anticancerogenic function. Moreover, we summarize data on chemotherapeutic application of redox active selenium compounds. (2) Methods: In the first section, main aspects of metabolism and redox activity of selenium compounds is reviewed. The second outlines multiple biological functions, asserted when selenium is incorporated into the structure of selenoproteins. The final section focuses on anticancer activity of selenium and chemotherapeutic application of redox active selenium compounds as well. (3) Results: optimal dietary level of selenium ensures its proper antioxidant and anticancer activity. We pay special attention to antioxidant activities of selenium compounds, especially selenoproteins, and their importance in antioxidant defence. It is worth noting, that data on selenium anticancer properties is still contraversive. Moreover, selenium compounds as chemotherapeutic agents usually are used at supranutritional doses. (4) Conclusions: Selenium play a vital role for many organism systems due to its incorporation into selenoproteins structure. Selenium possesses antioxidant activity at optimal doses, while at supranutritional doses, it displays prooxidant activity. Redox active selenium compounds can be used for cancer treatment; recently special attention is put to selenium containing nanoparticles.

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Section: Selenium and Cancermentioning

confidence: 99%

Section: Selenium and Cancermentioning

confidence: 99%

Selenium Anticancer Properties and Impact on Cellular Redox Status

et al. 2020

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“…The trace element selenium is an essential nutraceutical for human health and has attracted a great attention, because of its potential in cancer treatment and chemoprevention [ 3 , 4 ]. Selenium compounds have been intensively studied, in many experimental models, against several malignancies, including lung cancer [ 3 ]. A variety of clinical trials were conducted to evaluate the safety and efficacy of selenium in lung cancers patients [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…The selenium compounds used in preclinical and clinical studies can be broadly categorized into organic and inorganic forms. Animal data have shown that the organic forms of selenium are both safer and more effective than the commonly-used inorganic forms, such as sodium selenite [ 3 ]. A recognized source of organic food-form is the selenium yeast (SY), which is produced by growing select strains of Saccharomyces cerevisiae in selenium-rich media [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

“…A recognized source of organic food-form is the selenium yeast (SY), which is produced by growing select strains of Saccharomyces cerevisiae in selenium-rich media [ 25 ]. It predominantly contains l -selenomethionine [ 3 ] and the safety record is excellent [ 25 ]. In the present study, we found a synergistic apoptotic response between SY and FO in human LADC cell lines.…”

Section: Introductionmentioning

confidence: 99%

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Opposite Regulation of CHOP and GRP78 and Synergistic Apoptosis Induction by Selenium Yeast and Fish Oil via AMPK Activation in Lung Adenocarcinoma Cells

et al. 2018

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Selenium has been intensively studied for the use of cancer prevention and treatment. However, the clinical effects are still plausible. To enhance its efficacy, a combinational study of selenium yeast (SY) and fish oil (FO) was performed in A549, CL1-0, H1299, HCC827 lung adenocarcinoma (LADC) cells to investigate the enhancement in apoptosis induction and underlying mechanism. By sulforhodamine B staining, Western blot and flow cytometric assays, we found a synergism between SY and FO in growth inhibition and apoptosis induction of LADC cells. In contrast, the fetal lung fibroblast cells (MRC-5) were unsusceptible to this combination effect. FO synergized SY-induced apoptosis of A549 cells, accompanied with synergistic activation of AMP-activated protein kinase (AMPK) and reduction of Cyclooxygenase (COX)-2 and β-catenin. Particularly, combining with FO not only enhanced the SY-elevated proapoptotic endoplasmic reticulum (ER) stress marker CCAAT/enhancer-binding protein homologous protein (CHOP), but also reduced the cytoprotective glucose regulated protein of molecular weight 78 kDa (GRP78). Consequently, the CHOP downstream targets such as phospho-JNK and death receptor 5 were also elevated, along with the cleavage of caspase-8, -3, and the ER stress-related caspase-4. Accordingly, inhibition of AMPK by compound C diminished the synergistic apoptosis induction, and elevated CHOP/GRP78 ratio by SY combined with FO. The AMPK-dependent synergism suggests the combination of SY and FO for chemoprevention and integrative treatment of LADC.

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