Optimising regulatory T cell (Treg) depletion in combination with chemotherapy for enhanced anti-tumour immunity

Alistair, Cook; Alison, M Dunning; Bruce, Robinson; Richard, L; Millward, Michael; Nowak, Adriana

doi:10.3389/conf.fimmu.2013.02.00925

Cited by 1 publication

(1 citation statement)

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“…Additionally, the same study observed a reduced Treg cell population in peripheral blood from NSCLC patients after four cycles of docetaxel-based chemotherapy. In another small study, effect of a low dose of cyclophosphamide (CTX) was investigated for selective depletion of Treg cells in conjunction with pemetrexed-based NSCLC chemotherapy [90]. While Treg cell numbers were unaffected, activated T-effector cells were increased, suggesting CTX may affect Treg cell function.…”

Section: Th1 and Th2 Cells In Immune Modulationmentioning

confidence: 99%

Cellular and molecular immunology of lung cancer: therapeutic implications

Nguyen

Berim

Agrawal

2014

Expert Review of Clinical Immunology

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Though incidence is declining, the prognosis of lung cancer remains poor. This is likely due to lack of early detection and only recent developments in selective cancer therapies. Key immune cells involved in the pathogenesis of lung cancer include CD4+ T-lymphocytes, macrophages, dendritic cells, and natural killer cells. The growing understanding of these cells indicates a highly complex and intertwined network of their involvement in each stage of lung cancer. Immune cell types and numbers affect prognosis and could offer an opportunity for clinical therapeutic applications. However, an incomplete understanding of immune cell involvement and the underlying processes in lung cancer still remain. More investigation focusing on the role of the immune cells will further the understanding of lung carcinogenesis and develop novel therapeutic approaches for the treatment and management of patients with more specialized and selective lung cancer.

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Section: Th1 and Th2 Cells In Immune Modulationmentioning

confidence: 99%