“…To overcome these limitations we, and others, have reported extensively on the use of dibromomaleimides (DBMs), [16][17][18][19][20][21][22][23] and related substituted maleimides known collectively as next generation maleimides (NGMs). 20,24 These reagents retain the favourable kinetics of maleimides 25,26 whilst avoiding the formation of stereoisomers, and through the addition of two thiols allow the construction of dual conjugates (Fig. 1B).…”