Optimisation of the process conditions for the modification of starch

Tijsen, C.J; Scherpenkate, H.J.; Stamhuis, Eize; Beenackers, A.A.C.M.

doi:10.1016/s0009-2509(98)00321-2

Cited by 49 publications

(36 citation statements)

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“…Carboxymethyl starch is a popular chemically modified starch. It is prepared by a reaction of starch (St-OH) and sodium monochloroacetate (SMCA) (ClCH 2 COO − Na + ) in the presence of sodium hydroxide (NaOH) (2)(3)(4)(5). This is a two-step reaction that proceeds as…”

Section: Introductionmentioning

confidence: 99%

“…Such an approach gives no insight into the interactions between the process variables unless a large number of combinations are carried out. A statistical approach using experimental design combined with response surface methodology can be employed to simultaneously study the influence of multiple factors on interesting responses (2,10). A Box-Behnken design (11) or an orthogonal balanced incomplete block design is an economical design for an experiment, which has three or more factors.…”

Section: Introductionmentioning

confidence: 99%

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Preparation and Application of Carboxymethyl Yam (Dioscorea esculenta) Starch

2009

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Abstract. Yam (Dioscorea esculenta) starch was modified by carboxymethylation. The effect of reaction parameters, amount of sodium hydroxide (NaOH), amount of sodium monochloroacetate (SMCA), and reaction time on the degree of substitution (DS) of carboxymethyl yam starch (CMS), was studied using the Box-Behnken experimental design. Physicochemical and potency to be a tablet disintegrant of CMS were evaluated. CMS with DS in the range of 0.08-0.19 were obtained. The results from regression analysis indicated that the most important factor in controlling DS was the amount of NaOH followed by SMCA content and reaction time. However, high concentration of NaOH and SMCA lowered the DS. The optimal conditions to achieve the highest DS (0.19) were found to be at molar ratios of NaOH and SMCA to anhydroglucose unit of 1.80 and 2.35, respectively, and with the reaction time of 4.8 h. The swelling power and viscosity of CMS increased with an increase in the degree of modification. CMS showed satisfying tablet disintegrant properties. The tablets containing 1.0-4.0 % CMS disintegrated faster than 5 min. Hence carboxymethyl yam starch can be used as an excellent tablet disintegrant in low concentration.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Preparation and Application of Carboxymethyl Yam (Dioscorea esculenta) Starch

2009

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“…SN2 reaction of the alkoxide formed with SMCA to form CM-CAG. (2) The side reaction occurs in both the liquid bulk as well as the gum phase (Tijsen, Scherpenkate, Stamhuis, & Beenackers, 1999). The side reaction results in the formation of sodium glycolates from NaOH and SMCA.…”

Section: Resultsmentioning

confidence: 99%

Carboxymethylation of Cassia angustifolia seed gum: Synthesis and rheological study

Rajput¹,

Pandey²,

Joshi

2015

Carbohydrate Polymers

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“…A side reaction, shown below, takes place simultaneously in both liquid bulk and gum phase resulting in the formation of sodium glycolate from sodium monochloroacetate and sodium hydroxide [45]. Thus, the optimization study on the carboxymethylation process was carried out to improve substitution of the carboxymethyl groups in GG, while minimizing the undesired side reaction.…”

Section: Gg Ona Clch Cooh Gg Och Coona Naclmentioning

confidence: 99%

Development of novel thiolated carboxymethyl-gellan gum as potential mucoadhesive polymer: Application of DoE

More¹,

Bhamare²,

Bhavsar³

et al. 2017

Adv Mater Sci

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The objective of the present investigation was to synthesize soluble carboxymethyl-gellan gum (CMG) from gellan gum (GG) using statistical experimental design (DoE) strategy. Experimental design can potentially calculate the optimum reaction condition required to obtain response i.e. degree of substitution (DS) of CMG, which was statistically assessed. The effect of two process factors, namely concentration of monochoroacetic acid and water:isopropanol ratio on DS was investigated. Another objective of present study was to improve the mucoadhesive strength of optimized CMG by its covalent attachment with thiol moieties so as to get thiolated carboxymethyl-gellan gum (TCG). Synthesized CMG and TCG were characterized by FT-IR, DSC and NMR. Polymer compacts of TCG exhibited 3.73 fold greater adhesive strength on goat intestinal mucosa as compared with bare GG. In accordance with the promising results obtained; synthesized TCG can be considered as potential modified polymer for further drug delivery applications, especially mucoadhesive systems.

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Optimisation of the process conditions for the modification of starch

Cited by 49 publications

References 0 publications

Preparation and Application of Carboxymethyl Yam (Dioscorea esculenta) Starch

Preparation and Application of Carboxymethyl Yam (Dioscorea esculenta) Starch

Carboxymethylation of Cassia angustifolia seed gum: Synthesis and rheological study

Development of novel thiolated carboxymethyl-gellan gum as potential mucoadhesive polymer: Application of DoE

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