“…Harbourne et al (2009) reported that Matricaria chamomilla presented similar contents of phenolic compounds, with values ranging between 1.46 and 2.45 g GAE/100 g.…”
“…Harbourne et al (2009) reported that Matricaria chamomilla presented similar contents of phenolic compounds, with values ranging between 1.46 and 2.45 g GAE/100 g.…”
“…Infusions and essential oils are used in a number of commercial products including soaps, detergents, perfumes, lotions, ointments, hair products, baked goods, confections, alcoholic beverages and herbal teas (Gupta, Mittal, Bansal, Khokra, & Kaushik, 2010). Traditionally, chamomile flowers are prepared as an infusion with water, to make an herbal tea (Harbourne, Jacquier, & O'Riordan, 2009). Recent research supports this use and shows that these properties are partly due to the phenolic content (Maschi et al, 2008;McKay, & Blumberg, 2006).…”
Natural products represent a rich source of biologically active compounds and are an example of molecular diversity, with recognized potential in drug discovery. Herein, methanol extract of Matricaria recutita L. (German chamomile) and its decoction and infusion (the most consumed preparations of this herb) were submitted to an analysis of phytochemicals and bioactivity evaluation. The antioxidant activity was determined by free radicals scavenging activity, reducing power and inhibition of lipid peroxidation; the antitumour potential was tested in human tumour cell lines (breast, lung, colon, cervical and hepatocellular carcinomas), and the hepatotoxicity was evaluated using a porcine liver primary cell culture (non-tumour cells). All the samples revealed antioxidant properties. Decoction had no antitumour activity (GI 50 >400 µg/mL) which could indicate that this bioactivity might be related to compounds (including phenolic compounds) that were not extracted or that were affected by the decoction procedure.Both plant methanol extract and infusion showed inhibitory activity of the growth of HCT-15 (GI 50 250.24 and 298.23 µg/mL, respectively) and HeLa (GI 50 259.36 and 277.67 µg/mL, respectively) cell lines, without hepatotoxicity (GI 50 >400 µg/mL).Infusion and decoction gave higher contents of organic acids (24.42 and 23.35 g/100 g dw). Otherwise, the plant methanol extract presented the highest amounts of phenolic acids (3.99 g/100 g dw) and flavonoids (2.59 g/100 g dw). The major compound found in all the preparations was luteolin O-acylhexoside. Overall, German chamomile contains important phytochemicals with bioactive properties (mainly antitumour potential selective to colon and cervical carcinoma cell lines) to be explored in the medicine, food, and cosmetic industries.
“…Prior to inclusion into beverages these herbs undergo post-harvest processing, including drying, to extend their shelf-life. Previous studies have shown that preservation techniques of medicinal herbs may affect their quality (Harbourne, Jacquier, & O'Riordan, 2009;Julkunen-Tiitto & Sorsa, 2001). For a high quality extract for incorporation into a beverage the level of phenolics should be maximized, in particular the non-tannin fractions which will include the active ingredients with anti-inflammatory properties.…”
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