Optimisation of polyphenol extraction from Hypericum perforatum (St. John's Wort) using aqueous glycerol and response surface methodology

Karakashov, Blagoj; Grigorakis, Spyros; Loupassaki, Sofia; Makris, Dimitris P.

doi:10.1016/j.jarmap.2014.11.002

Cited by 53 publications

(42 citation statements)

References 35 publications

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“…One gram of dried onion peel powder was added to individual DESs at a liquid–solid ratio of 50:1 (v/w) and stirred for 3 h at 80 °C in a water bath. Water was added to these solutions in varying proportions to reduce viscosity and facilitate subsequent extractions . The slurry was filtered through Whatman filter paper No.…”

Section: Methodsmentioning

confidence: 99%

“…Water was wileyonlinelibrary.com/jsfa added to these solutions in varying proportions to reduce viscosity and facilitate subsequent extractions. 22,24 The slurry was filtered through Whatman filter paper No. 1 thrice and resulting extracts were subsequently analyzed for total phenolic content (TPC) using the Folin-Ciocalteu method.…”

Section: Extraction By Heating Soxhlet and Microwave-assisted Extracmentioning

confidence: 99%

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Deep eutectic solvent‐based extraction of polyphenolic antioxidants from onion (Allium cepa L.) peel

2018

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BACKGROUND Biomass waste, including fruit and vegetable residues, poses a serious challenge to the environment. This demands novel approaches for handling and disposing of it in a safe manner. However, such waste is extremely rich in bioactive components, which are considered to have a beneficial impact on health. This has led to the recovery of high‐value compounds from biomass waste before finally disposing of it. The present investigation reveals the use of green solvents such as eutectic mixtures composed of choline chloride with three different hydrogen bond donors like sucrose (4:1), urea (1:2), and sorbitol (3:1) as extractants for recovering valuable phenolic antioxidants from onion peel. RESULTS A deep eutectic solvent system consisting of choline chloride:urea (ChCl:urea) showed the best result for total phenolic content from onion peel while the other two eutectic mixtures showed relatively lower extraction efficiency. Experiments were performed with different molar ratios of ChCl:U (1:1–1:3) and liquid–solid ratios (10:1–60:1) under a temperature range (50–90 °C) and a time range (60–150 min). Taguchi's method was employed to maximize the extraction of polyphenolic antioxidants from onion peel, resulting in optimal conditions: extraction temperature 60 °C, time 120 min, liquid to solid ratio 50:1 and molar ratio of ChCl:U as 1:2. Under optimum conditions, the corresponding TPC value of the extract was found to be highest at 222.97 mg gallic acid equivalent (GAE) g−1 dw. CONCLUSION Major flavonoids – quercetin, kaempferol, and myricetin – were identified and quantified in the extracts. Moreover, high reducing power (PR) value was reported in the case of ChCl:U extract, and 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) radical scavenging activity was found to be higher in ChCl:So extract. © 2018 Society of Chemical Industry

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Section: Methodsmentioning

confidence: 99%

Section: Extraction By Heating Soxhlet and Microwave-assisted Extracmentioning

confidence: 99%

Deep eutectic solvent‐based extraction of polyphenolic antioxidants from onion (Allium cepa L.) peel

2018

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“…The polyphenol content was calculated by a first‐order equation ( Y = 511.86 X – 28.634, R 2 = 1) obtained from a gallic acid standard curve (0 to 500 ppm) and expressed as mg gallic acid equivalents per gram of extract by dry weight basis (mg GAE/g of extract DW). Moreover, total polyphenol yield (TPY) was expressed as mg GAE per gram of rosemary leaves dry weight (Karakashov, Grigorakis, Loupassaki, & Makris, ) to compare with results of other studies using this unit for polyphenol content of plant material.…”

Section: Methodsmentioning

confidence: 99%

Optimization of heat- and ultrasound-assisted extraction of polyphenols from dried rosemary leaves using response surface methodology

Hosseini

Bolourian

Hamgini

et al. 2018

J Food Process Preserv

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The conditions used in heat‐ and ultrasound‐assisted extraction (HAE and UAE, respectively) of polyphenols from rosemary leaves were optimized using response surface methodology. The optimum HAE conditions included an extraction time of 132.80 min, temperature of 70°C, and 20:1 liquid‐to‐solid ratio, resulting in the maximum total extraction yield (TEY, 17.80%) or total polyphenol content (TPC, 147.56 mg GAE/g of extract DW), and minimum IC50 (994.68 μg/ml); the maximum TEY (20.82%) or TPC (185.16 mg GAE/g of extract DW), and minimum IC50 (805.84 μg/ml) in the UAE process were obtained using optimum conditions, including time of 12.60 min, power of 200 W, and ethanol concentration of 56.26%. The lowest IC50 (787.70 μg/ml) was recorded using a solvent mixture of water and ethanol (56%) in the HAE procedure similar to the amount determined for the BHT antioxidant (714.79 μg/ml), thus confirming the efficiency of the extraction procedure. Practical applications The antioxidant properties of rosemary leaves are well characterized; hence, this plant’s extract is approved as the only accepted natural food antioxidant in the EU. Generally, the extraction of active compounds from rosemary leaves is performed by the HAE method. However, it is recommended to use sustainable technologies, such as UAE. The optimization of both conventional and UAE of polyphenols from rosemary leaves has not been studied in the literature. Therefore, the purpose of the present study was to introduce the optimal conditions of the HAE and UAE methods required to obtain maximum extraction efficiency of polyphenol compounds from rosemary leaves, and then was to compare possible procedures so that a comprehensive method to be developed.

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“…Previous studies demonstrated that water/glycerol mixtures may be very effective in extracting polyphenols [7,8], but the information available to date is rather poor to fully evaluate glycerol's potency for efficient polyphenol recovery from plant material. Such an evaluation would embrace kinetic studies [9], to ascertain the efficacy and rapidity of extraction, carried out with a given solvent system.…”

Section: Resultsmentioning

confidence: 99%

Kinetics of Ultrasound-Assisted Flavonoid Extraction from Agri-Food Solid Wastes Using Water/Glycerol Mixtures

Makris

2016

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Red grape pomace (RGP) and onion solid wastes (OSW) were used as raw material to produce flavonoid-enriched extracts, using ultrasound-assisted solid-liquid extraction. The extraction medium used was composed of water and glycerol and under the conditions used the extraction of flavonoids from both materials was shown to obey first-order kinetics. Maximum diffusivities (D e ) values were 4.01ˆ10´1 1 and 2.35ˆ10´1 1 m 2¨s´1 , for RGP and OSW extraction, respectively, while the corresponding activation energies (E a ) were 14.00 and 15.23 kJ¨mol´1.

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Optimisation of polyphenol extraction from Hypericum perforatum (St. John's Wort) using aqueous glycerol and response surface methodology

Cited by 53 publications

References 35 publications

Deep eutectic solvent‐based extraction of polyphenolic antioxidants from onion (Allium cepa L.) peel

Deep eutectic solvent‐based extraction of polyphenolic antioxidants from onion (Allium cepa L.) peel

Optimization of heat- and ultrasound-assisted extraction of polyphenols from dried rosemary leaves using response surface methodology

Kinetics of Ultrasound-Assisted Flavonoid Extraction from Agri-Food Solid Wastes Using Water/Glycerol Mixtures

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