Optimisation of platelet concentrates therapy: Composition, localisation, and duration of action

Yung, Yuk‐Lin; Fu, Sai‐Chuen; Cheuk, Yau-Chuk; Qin, Ling; Ong, Michael Tim‐Yun; Chan, Kai‐Ming; Yung, Patrick Shu‐Hang

doi:10.1016/j.asmart.2016.11.003

Cited by 27 publications

(30 citation statements)

References 132 publications

(168 reference statements)

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“…Several parameters must be taken into account when preparing and using PRP: platelet concentration; concentration of platelets above baseline; whether leukocytes are included; erythrocytes and whether they should be activated before use; methods of delivery; number of injections or applications (topical); localization of PRP . Therefore, there is a need for a standardized protocol for PRP preparation and therapy …”

Section: Discussionmentioning

confidence: 99%

Application of standardized platelet‐rich plasma in elderly patients with complex wounds

Tian

Cheng

Chen

et al. 2019

Wound Repair Regeneration

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In recent years, autologous platelet-rich plasma (PRP) derivatives have been used widely in the regeneration and repair of tissue, but a standard definition and preparation method for PRP are lacking. We developed a standardized method using platelet indices as quality-control indicators for PRP preparation. Twenty-one elderly patients (9 males, 12 females) with complex wounds were treated with standardized platelet-rich plasma (S-PRP). The platelet count in PRP after the second centrifugation was 1,069-1,436 × 10 9 /L. We adjusted the platelet concentration in PRP after a second centrifugation to 1,000 × 10 9 /L according to a formula using platelet-poor plasma (PPP). The standardized preparation method that we developed gave S-PRP with a relatively uniform platelet concentration. The wounds of 21 patients showed accelerated healing after S-PRP treatment, and there were no obvious side effects during treatment. These data suggest that our preparation method of S-PRP, using platelet indices as quality-control indicators with platelet count of 1,000 × 10 9 /L could be used for the treatment of complex wounds in the elderly. The preparation method of S-PRP proposed in the present study may be a simple and effective method of PRP quality control.

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Section: Discussionmentioning

confidence: 99%

Application of standardized platelet‐rich plasma in elderly patients with complex wounds

Tian

Cheng

Chen

et al. 2019

Wound Repair Regeneration

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“…Kas iskelet sistemi patolojilerinde son yıllarda gittikçe artan bir sıklıkla rejeneratif tedavilere başvurulmaktadır. Eklem, kas, kıkırdak sorunlarının yanında tendon hasarları da PRP tedavilerinin sıklıkla uygulandığı patolojilerdir (15)(16)(17)(18)(19)(20)(21) hastada manyetik rezonans (MR) artrogramda rotator kaf yırtığında %50 azalma saptandığı ayrıca ağrı ve fonksiyonel durumda düzelme olduğu belirtilmiştir. Bizim çalışmamızla oldukça benzerlik gösteren bir çalışmada ise rotator kaf tendon patolojisi olan bir gruba PRP bir gruba ise kortizon uygulanmıştır.…”

Section: Discussionunclassified

Comparison of Platelet-rich Plasma and Cortisone Injections Administered Under Ultrasonography Guidance in Rotator Cuff Tendon Pathologies

Subaşı¹

2019

Tod

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Objective: Rotator cuff tendon pathologies are the most frequently diagnosed disease group among the causes of shoulder pain. The aim of this study was to compare the results of platelet-rich plasma (PRP) and cortisone treatments applied to patients who admitted to our outpatient clinic with the diagnosis of Rotator cuff syndrome. Materials and Methods: A total of 40 patients with no shoulder movement restriction and shoulder pain longer than 3 months were included in the study. Pain symptoms of the patients were evaluated with Visual Analogue Scale (VAS) and functional status with the disabilities of the arm, shoulder and hand score (Quick-DASH). Results: Statistically significant improvements were observed in the VAS and Quick-DASH scores at the first and second month controls (according to the first month and pre-treatment) in the evaluations of the both groups (p<0.01). In the statistical study comparing clinical recovery in both groups, it was found that there was a further decrease in the PRP group at the second month control only in the VAS scores (p=0.007) and this difference was found to be statistically significant, while the decrease in the Quick-DASH scores was found to be statistically similar (p=0.007). Conclusion: In this study, we concluded that PRP and cortisone injections were effective in rotator cuff lesions. We believe that the PRP therapy is a good alternative to rotator cuff lesions in patients with comorbid diseases or in patients who cannot be treated with cortisone because of the adverse effects.Amaç: Rotator kaf tendon patolojileri omuz ağrısı yapan nedenler arasında en sık saptanan hastalık grubunu oluşturmaktadır. Rotator kaf sendromu tanısı ile polikliniğimize başvuran hastalara uygulanan plateletten zengin plazma (PRP) ve kortizon tedavilerinin sonuçlarının karşılaştırılması amaçlanmıştır. Gereç ve Yöntem: Çalışmaya ileri derecede omuz hareket kısıtlılığı olmayan, 3 aydan uzun süreli omuz ağrısı olan toplam 40 hasta dahil edildi. Hastaların ağrı yakınması Visüel Analog Skala (VAS) ve fonksiyonel durumu ise kol, omuz ve el sorunları anketi (Quick-DASH) ile değerlendirildi. Bulgular: Her iki grubun kendi içindeki değerlendirmelerinde birinci ay ve ikinci ay kontrollerinde (birinci aya ve tedavi öncesine göre) VAS ve Quick-DASH skorlarında istatistiksel olarak anlamlı düzelmeler kaydedildi (p<0,01). Her iki grupta oluşan klinik iyileşmenin kıyaslandığı istatistiksel çalışmada ise sadece VAS skorlarında 2. ay kontrolünde PRP grubunda daha fazla azalma olduğu ve bu farkın istatistiksel olarak anlamlı olduğu saptandı (p=0,007). Quick-DASH skorlarındaki azalmanın ise istatistiksel olarak benzer olduğu saptandı (p=0.007). Sonuç: Sonuç olarak yaptığımız çalışmada rotator kaf lezyonlarında PRP ve kortizon enjeksiyonları tedavilerinin etkili olduğu sonucuna vardık. Komorbid hastalıkları olan kişilerde, yan etkileri nedeniyle kortizon tedavisi uygulanamayan hastalarda PRP tedavisinin rotator kaf lezyonlarında iyi bir tedavi alternatifi olduğu kanısındayız. Anahtar kelimeler: Rotator kaf lezyonl...

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“…Platelet preparations may be classified based on the presence of individual components [62]. The most common form of platelet concentrates is pure PRP and leukocyte PRP.…”

Section: Il-6mentioning

confidence: 99%

Platelet-rich plasma or blood-derived products to improve endometrial receptivity?

Bös-Mikich

Ferreira

Oliveira³

et al. 2019

J Assist Reprod Genet

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The use of platelet-rich plasma (PRP) to improve endometrial receptivity is gaining increasing attention in assisted reproduction technologies. The authors report that autologous PRP intrauterine administration improves pregnancy and birth rates, particularly in cases of patients presenting poor endometrial growth. Different groups of scientists proposed a similar approach years ago using whole blood-derived products also to improve endometrial receptivity. The important role played by cytokines and growth factors during embryo implantation has been well-known for a long time. These signaling molecules are present and released by blood cells during physiological, normal endometrial growth and implantation. Similar blood mediators are released from platelet granules upon a blood vessel injury. Methods described for PRP preparation for intrauterine administration are not precise, and they seem to be similar to those used to prepare peripheral blood-derived products. Thus, it is possible that when preparing PRP from whole blood, the final plasma product used as BPRP^contains platelets in addition to the important cytokines and growth factors released by the peripheral blood mononuclear cells present in the whole blood. Precise knowledge of the identity, concentration, and effects of the individual blood factors, their origin, whether platelets or blood mononuclear cells, will greatly contribute to improve and to make results obtained in fertility treatments more repeatable.

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Optimisation of platelet concentrates therapy: Composition, localisation, and duration of action

Cited by 27 publications

References 132 publications

Application of standardized platelet‐rich plasma in elderly patients with complex wounds

Application of standardized platelet‐rich plasma in elderly patients with complex wounds

Comparison of Platelet-rich Plasma and Cortisone Injections Administered Under Ultrasonography Guidance in Rotator Cuff Tendon Pathologies

Platelet-rich plasma or blood-derived products to improve endometrial receptivity?

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