“…The literature analysis for the last 15 years shows that a variation of amide and alkyl(aryl) substituents in fluoroaromatic ring of salicylic acid is favorable approach to bioactive molecules synthesis. A number of biologically active compounds was obtained based on this strategy, e. g., potent non‐nucleoside HBV inhibitors, myxochelin‐inspired 5‐lipoxygenase inhibitors, antimicrobial and antibacterial agents,, potent inhibitors of RANKL‐induced osteoclastogenesis and bone resorption, anti‐EV71 agents via cyclophilin A inhibition, selective kappa opioid receptor agonists, antituberculous agents, inhibitors of toxoplasma gondii, anti‐hepatitis B virus, and anti‐HIV‐1 agents, inhibitors of the molecular chaperone heat shock protein 90 (Hsp90), CCR3 antagonists, inhibitors of type III secretion in Yersinia, inhibitors of aldose reductase for treatment of chronic diabetic complications, inhibitors of the menin‐MLL interaction, CD73 inhibitors, pyruvate dehydrogenase kinase inhibitors, anticancer agents,, KCNQ2/3 modulators, anticoagulants, anti‐inflammatory agents and analgesics,, antidiabetic agents,, RORc modulators, PGD2 receptor antagonists…”