Optimisation of green ultrasonic cell grinder extraction of iridoid glycosides from Corni fructus by response surface methodology

Abstract

Summary Ultrasonic cell grinder extraction (UCGE), employing water as solvent, was proposed as a sustainable and efficient method for the extraction of two iridoid glycosides (morroniside and loganin) from Corni fructus. Extraction yields were determined by four variables: ratio of solution to solid, extraction power, extraction buffer time and extraction time. Data analysis by response surface methodology showed that best yields, 2.176% ± 0.006% (predicted value of 2.195%) for morroniside and 0.839% ± 0.004% (predicted value of 0.852%) for loganin, were obtained when the values of these four variables were set at 45:1 mL g−1, 1600 w, 2.3 s and 40 min, respectively. The yields of morroniside and loganin using UCGE method were 0.198–0.279% and 0.167–0.181% higher than that of traditional heat reflux extraction method, respectively. Thus, the UCGE method is more productive, economic and environmentally friendly and has great potential to be used widely in natural product chemistry.

Optimization of green extraction of anthocyanins from purple passion fruit peels by response surface methodology

“…A single‐factor experiment was designed to evaluate the effect of each factor on the extraction yield. The initial condition were established such that a 10 g sample was extracted with 200 mL of 60% ethanol containing 0.01% HCl (v/v) at 600 W extraction power, 1.5 s buffer time, 2 s cavitation time, and 35 min extraction time (He, Zhang, Yue, Liang, & Gao, ; Xie, Chen, Yu, & Shi, ). The effect of ethanol concentration, ratio of solution to solid, extraction time, extraction power, buffer time, and cavitation time were investigated as follows: one factor was changed while the other factors remained fixed in each experiment.…”

“…Hence, pure water was used as the extraction solvent (Feng, Luo, Tao, & Chen, 2015). The other minor influencing factor was the cavitation time, which was the same as used in previous report, and therefore, 1.5 s was established as an appropriate time (Xie et al, 2014). In solid-liquid extraction, the proper ratio of solution to solid is a significant variable.…”

Cornus officinalis Extract Enriched with Ursolic Acid Ameliorates UVB-Induced Photoaging in Caenorhabditis elegans

“…As a traditional Chinese medicine, it is a famous health food and is extensively distributed throughout China. Cornus officinalis contains a variety of active ingredients, mainly including iridoid glycosides, polysaccharides, triterpenoids, phenols, and flavonoids, which grant its immune regulation, antioxidant, and anti-aging functions [ 10 , 11 , 12 , 13 , 14 ]. Thus, it is used for food and cosmetic purposes [ 15 ].…”

Ultrasonic Cell Grinder Extraction of Cyperenoic Acid from Crotonis Crassifolii Radix and the Activity Assay of the Extract

“…Thus, the UCGE has been gradually applied to traditional Chinese medicine and functional foods. [19][20][21] Considering the advantage of UCGE, it was introduced to extract cyperenoic acid from the herb residue. Meanwhile, the optimisation of the process is also an important part of an extraction.…”

“…In UCGE, ultrasonic energy can destroy the plant cell membrane, accelerate the molecular movement, and improve the mass transfer rate. Thus, the UCGE has been gradually applied to traditional Chinese medicine and functional foods [19–21] …”