Optimisation of an in vitro human cardiovascular model on-a-chip for toxicological assessment of nicotine delivery products
Fiona Chapman,
Luuk de Haan,
Linda Gijzen
et al.
Abstract:BackgroundSmoking cigarettes is a cause of serious diseases in smokers, including cardiovascular disease. Through a pathway of endothelial dysfunction, lipid infiltration, macrophage recruitment and vascular remodeling, atherosclerosis is fundamental in the development of most cardiovascular diseases. There is an increasing number of next-generation products (NGP) which provide potentially reduced harm forms of nicotine delivery to adult smokers. This study aimed to optimise an in vitro cardiovascular model to… Show more
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