Optimisation of a two-liquid component pre-filled acrylic bone cement system: a design of experiments approach to optimise cement final properties

Clements, JM; Walker, Gavin; Pentlavalli, Sreekanth; Dunne, Nicholas

doi:10.1007/s10856-014-5260-y

Cited by 3 publications

(5 citation statements)

References 31 publications

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“…The maximum temperature of cement's curing process is as high as 110°C; however, the extent of thermal necrosis depends not only on the maximum temperature but also on the exposure time . When the bone tissue is exposed to the temperature of 60°C or more, the bone necrosis appears regardless the time of exposure, whereas 47°C is estimated as a threshold temperature for bone necrosis . According to the ISO 5833:2002 standard the maximum temperature of acrylic bone cement curing should not exceed 90°C, which is well above the estimated threshold temperature …”

Section: Introductionmentioning

confidence: 99%

“…[15,16] When the bone tissue is exposed to the temperature of 60°C or more, the bone necrosis appears regardless the time of exposure, whereas 47°C is estimated as a threshold temperature for bone necrosis. [17,18] According to the ISO 5833:2002 standard the maximum temperature of acrylic bone cement curing should not exceed 90°C, which is well above the estimated threshold temperature. [18] Several different solutions have been proposed so far to reduce maximum curing temperature of PMMA bone cements.…”

Section: Introductionmentioning

confidence: 99%

“…[17,18] According to the ISO 5833:2002 standard the maximum temperature of acrylic bone cement curing should not exceed 90°C, which is well above the estimated threshold temperature. [18] Several different solutions have been proposed so far to reduce maximum curing temperature of PMMA bone cements. Among them, phase change materials (PCMs) can be used as bone cements modifiers.…”

Section: Introductionmentioning

confidence: 99%

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Modification of acrylic bone cements by poly(ethylene glycol) with different molecular weight

Król

Pielichowska

2016

Polymers for Advanced Techs

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The high polymerization temperature of acrylic bone cements can cause arthroplasty failure because of the thermal necrosis of surrounding bone tissue. To reduce this undesired effect we have developed novel acrylic bone cement composites containing a phase change material (PCM). As PCM poly(ethylene glycol) (PEG) of different molecular weight was applied and the effect of its incorporation on curing parameters, mechanical and morphological properties of acrylic bone cement was investigated. A significant decrease in maximum temperature from 65.8°C to 47.4°C and slight increase of setting time were observed. PEG introduction also contributed to the thermal stability of acrylic bone cement increase. SEM investigation of modified bone cement confirmed that the microstructure does not alter considerably because of PEG content. It was found that both PEG addition and incubation test contribute to an inconsiderable decrease in mechanical strength of bone cement. However, the mechanical strength increase can be caused by the fresh bone tissue incorporation into the pores appearing in bone cement.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Modification of acrylic bone cements by poly(ethylene glycol) with different molecular weight

Król

Pielichowska

2016

Polymers for Advanced Techs

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“…[177][178][179][180][181] Studying the effect of experimental factors on the reaction kinetics may guide the development of ABCs, and therefore, the design of experiments can be an effective approach to bone cement design, by enabling the identification of the dominant factors that influence its properties. 182 There is a limited number of literature reviews on viscoelastic properties of IBCs. 26,[183][184][185] The rheological properties of a cement may play a significant role in the formation of pores during cement mixing and delivery.…”

Section: Cement Characteristicsmentioning

confidence: 99%

“…177–181 Studying the effect of experimental factors on the reaction kinetics may guide the development of ABCs, and therefore, the design of experiments can be an effective approach to bone cement design, by enabling the identification of the dominant factors that influence its properties. 182…”

Section: Acrylic Bone Cementsmentioning

confidence: 99%

A review of calcium phosphate cements and acrylic bone cements as injectable materials for bone repair and implant fixation

Yousefi

2019

Journal of Applied Biomaterials & Functional Materials

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Treatment of bone defects caused by trauma or disease is a major burden on human healthcare systems. Although autologous bone grafts are considered as the gold standard, they are limited in availability and are associated with post-operative complications. Minimally invasive alternatives using injectable bone cements are currently used in certain clinical procedures, such as vertebroplasty and balloon kyphoplasty. Nevertheless, given the high incidence of fractures and pathologies that result in bone voids, there is an unmet need for injectable materials with desired properties for minimally invasive procedures. This paper provides an overview of the most common injectable bone cement materials for clinical use. The emphasis has been placed on calcium phosphate cements and acrylic bone cements, while enabling the readers to compare the opportunities and challenges for these two classes of bone cements. This paper also briefly reviews antibiotic-loaded bone cements used in bone repair and implant fixation, including their efficacy and cost for healthcare systems. A summary of the current challenges and recommendations for future directions has been brought in the concluding section of this paper.

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Nanostructured Strontium-Doped Calcium Phosphate Cements: A Multifactorial Design

et al. 2021

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Calcium phosphate cements (CPCs) have been extensively studied in last decades as nanostructured biomaterials for the regeneration of bone defects, both for dental and orthopedic applications. However, the precise control of their handling properties (setting time, viscosity, and injectability) still represents a remarkable challenge because a complicated adjustment of multiple correlated processing parameters is requested, including powder particle size and the chemical composition of solid and liquid components. This study proposes, for the first time, a multifactorial investigation about the effects of powder and liquid variation on the final performance of Sr-doped apatitic CPCs, based on the Design of Experiment approach. In addition, the effects of two mixing techniques, hand spatula (low-energy) and planetary shear mixing (high-energy), on viscosity and extrusion force were compared. This work aims to shed light on the various steps involved in the processing of CPCs, thus enabling a more precise and tailored design of the device, based on the clinical need.

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Optimisation of a two-liquid component pre-filled acrylic bone cement system: a design of experiments approach to optimise cement final properties

Cited by 3 publications

References 31 publications

Modification of acrylic bone cements by poly(ethylene glycol) with different molecular weight

Modification of acrylic bone cements by poly(ethylene glycol) with different molecular weight

A review of calcium phosphate cements and acrylic bone cements as injectable materials for bone repair and implant fixation

Nanostructured Strontium-Doped Calcium Phosphate Cements: A Multifactorial Design

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