“…Other related resampling‐based methods for identifying the number of clusters include Dudoit & Fridlyand (), Lange et al (), Levine & Domany () and Volkovich et al (). Using the prediction strength method requires a choice of test/training set size in the cross‐validation step, a challenging problem that has received some general attention in the literature (Afendras & Markatou, ; Markatou et al , ) but has not been investigated in the context of prediction strength. Additionally, the choice of threshold in the prediction strength method is recommended to be 0.8–0.9 for well‐separated clusters (Tibshirani & Walther, ), but in the event of clusters with less separation, or heterogeneous levels of separation, it is unclear how to best select a threshold.…”