Optimal wavelength combinations for near-infrared spectroscopic monitoring of changes in brain tissue hemoglobin and cytochrome c oxidase concentrations

Arifler, Dizem; Zhu, Tingting; Madaan, Sara; Tachtsidis, Ilias

doi:10.1364/boe.6.000933

Cited by 50 publications

(75 citation statements)

References 39 publications

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“…(In this opinion article, we explicitly assume that fNIRS instrumentation can accurately monitor and resolve the concentration changes in [ [HHb] as it has been reported that certain wavelength combinations can result in "crosstalk" between the chromophores. By crosstalk we mean to describe the phenomena that a genuine change in one chromophore concentration is also inducing a spurious measured concentration change in another; for a more detailed discussion of this issue see section "Selection of optimum wavelengths" in the recent review article by Scholkmann et al 4 and the recent study by Arifler et al 5 It is considered good practice for authors to report the wavelengths of their fNIRS instrument used in their study).…”

Section: Changes In Functional Near-infrared Spectroscopy Signals Repmentioning

confidence: 99%

False positives and false negatives in functional near-infrared spectroscopy: issues, challenges, and the way forward

2016

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Section: Changes In Functional Near-infrared Spectroscopy Signals Repmentioning

confidence: 99%

False positives and false negatives in functional near-infrared spectroscopy: issues, challenges, and the way forward

2016

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“…One strategy to overcome this limitation is to use a series of wavelengths in order to increase signal-to-noise ratio and to decrease cross talk artifacts. 90 In contrast to the two techniques mentioned in Secs. 2.4.1 and 2.4.2, here we use only two wavelengths emanating from coherent sources, which decrease our spectral resolution and accuracy.…”

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confidence: 98%

Noninvasive assessment of hemodynamic and brain metabolism parameters following closed head injury in a mouse model by comparative diffuse optical reflectance approaches

et al. 2016

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Abstract. Optical techniques have gained substantial interest over the past four decades for biomedical imaging due to their unique advantages, which may suggest their use as alternatives to conventional methodologies. Several optical techniques have been successfully adapted to clinical practice and biomedical research to monitor tissue structure and function in both humans and animal models. This paper reviews the analysis of the optical properties of brain tissue in the wavelength range between 500 and 1000 nm by three different diffuse optical reflectance methods: spatially modulated illumination, orthogonal diffuse light spectroscopy, and dualwavelength laser speckle imaging, to monitor changes in brain tissue morphology, chromophore content, and metabolism following head injury. After induction of closed head injury upon anesthetized mice by weight-drop method, significant changes in hemoglobin oxygen saturation, blood flow, and metabolism were readily detectible by all three optical setups, up to 1 h post-trauma. Furthermore, the experimental results clearly demonstrate the feasibility and reliability of the three methodologies, and the differences between the system performances and capabilities are also discussed. The long-term goal of this line of study is to combine these optical systems to study brain pathophysiology in high spatiotemporal resolution using additional models of brain trauma. Such combined use of complementary algorithms should fill the gaps in each system's capabilities, toward the development of a noninvasive, quantitative tool to expand our knowledge of the principles underlying brain function following trauma, and to monitor the efficacy of therapeutic interventions in the clinic.

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“…MC is computationally expensive and thus simulations were carried out at wavelengths 784, 800, 818, 835, 851, 868, 881 and 894 nm chosen according to. 16 Synthetic detectors were defined at 1, 2 and 3 cm (euclidean distance) to measure the exiting light mimicking the experimental setup. The synthetic detectors were 1 mm wide and were assumed to accept incoming photon with the same efficiency from all directions.…”

Section: Simulated Datamentioning

confidence: 99%

Modelling and validation of diffuse reflectance of the adult human head for fNIRS: scalp sub-layers definition

Herrera-Vega

Montero‐Hernández²,

Tachtsidis

et al. 2017

13th International Conference on Medical Information Processing and Analysis

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Accurate estimation of brain haemodynamics parameters such as cerebral blood flow and volume as well as oxygen consumption i.e. metabolic rate of oxygen, with funcional near infrared spectroscopy (fNIRS) requires precise characterization of light propagation through head tissues. An anatomically realistic forward model of the human adult head with unprecedented detailed specification of the 5 scalp sublayers to account for blood irrigation in the connective tissue layer is introduced. The full model consists of 9 layers, accounts for optical properties ranging from 750nm to 950nm and has a voxel size of 0.5mm. The whole model is validated comparing the predicted remitted spectra, using Monte Carlo simulations of radiation propagation with 10 8 photons, against continuous wave (CW) broadband fNIRS experimental data. As the true oxy-and deoxy-hemoglobin concentrations during acquisition are unknown, a genetic algorithm searched for the vector of parameters that generates a modelled spectrum that optimally fits the experimental spectrum. Differences between experimental and model predicted spectra was quantified using the Root mean square error (RMSE). RMSE was 0.071 ± 0.004, 0.108 ± 0.018 and 0.235 ± 0.015 at 1, 2 and 3cm interoptode distance respectively. The parameter vector of absolute concentrations of haemoglobin species in scalp and cortex retrieved with the genetic algorithm was within histologically plausible ranges. The new model capability to estimate the contribution of the scalp blood flow shall permit incorporating this information to the regularization of the inverse problem for a cleaner reconstruction of brain hemodynamics.

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Optimal wavelength combinations for near-infrared spectroscopic monitoring of changes in brain tissue hemoglobin and cytochrome c oxidase concentrations

Cited by 50 publications

References 39 publications

False positives and false negatives in functional near-infrared spectroscopy: issues, challenges, and the way forward

False positives and false negatives in functional near-infrared spectroscopy: issues, challenges, and the way forward

Noninvasive assessment of hemodynamic and brain metabolism parameters following closed head injury in a mouse model by comparative diffuse optical reflectance approaches

Modelling and validation of diffuse reflectance of the adult human head for fNIRS: scalp sub-layers definition

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