Optimal value of fractional exhaled nitric oxide in inhaled corticosteroid treatment for patients with chronic cough of unknown cause

Abstract

Using FeNO measurement as a rapid, noninvasive diagnostic tool for patients with chronic cough, ICS can be prescribed if the FeNO is 33.9 ppb or more.

Measurement of exhaled nitric oxide concentration in asthma: a systematic review and economic evaluation of NIOX MINO, NIOX VERO and NObreath

“…Of these, six 69,71,72,[82][83][84]86,87 were considered to be of most relevance to the decision problem, although the studies had not necessarily been conducted in the UK. l Nine studies [73][74][75][76][77]81,85,88,89,91 recruited patients who could be considered 'difficult to diagnose' and are located at other points along the diagnostic pathway. These patients had already undergone some of the tests in the UK pathway and had tested negative for asthma thus far.…”

“…One further study 71,72 reported a subset of difficult-to-diagnose patients from a larger cohort of patients at position A (see Figure 8). Of these, seven studies 73,74,76,77,81,85,88 were considered to be of most relevance to the decision problem, although the studies had not necessarily been conducted in the UK. l One study 78 recruited patients with suspected EIB.…”

“…These studies are Schneider et al, 69 Schneider et al, 71,72 Schleich et al, 77 Prieto et al, 76 El Halawani et al, 78 Hsu et al, 73 Hahn et al, 74 Pedrosa et al, 85 Heffler et al, 82 Smith et al 83 (de la Barra et al 84 reports additional analyses to Smith et al 83 ) Smith et al, 86 Bobolea et al, 88 Cordeiro et al 87 and Katsoulis et al…”

“…The overall study quality was variable, with the study by Smith et al 83 scoring well on all of the domains and thus being at least risk of bias. The studies at highest risk appeared to be those by Hsu et al 73 and Cordeiro et al, 87 neither of which provided sufficient information on the nature of blinding for the index and reference standard tests. There were also some issues in terms of patient flow in both studies.…”

“…Quality assessment of studies relevant to the decision problem Sixteen studies (18 citations 69,[71][72][73][74][76][77][78][80][81][82][83][84][85][86][87][88]92 ) exploring FeNO measurement for the diagnosis of asthma in adults were assessed for quality according to QUADAS-2 criteria for diagnostic accuracy studies. 38 Although based on the same data as the study by Smith et al, 83 the study by de la Barra et al 84 was assessed separately as the analysis was different.…”