Optimal treatment regimens for patients with bleeding disorders

Brown, Simon; Aledort, Louis M.; Lee, Christine A.; Barrowcliffe, T W; Beeton, Karen; Blanchette,; Bolland, Silvia; Goddard, N J; Goodeve, Anne; Hoyer, Linda Grace; Kessler, Craig M.; Ljung, Rolf; Lollar, Pete; Manco‐Johnson, Marilyn J.; Mariani, Guglielmo; Peerlinck, C; Rivard, Georges E.

doi:10.1046/j.1365-2516.2001.00525.x

Cited by 7 publications

(1 citation statement)

References 35 publications

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“…Therefore, both dentists and hematologists must be involved in treatment planning to avoid a life-threatening complication. They must discuss possible complications and perioperative management to ensure safe dental care [18]. In general, patients with platelet counts of at least 30 × 10 3 /μL require no treatment unless a procedure inducing blood loss is required, such as a dental extraction [10], which can result in major bleeding complications in patients with platelet counts lower than 100 × 10 3 /μL [19].…”

Section: Discussionmentioning

confidence: 99%

Life-threating outcomes after dental implantation in patient with idiopathic thrombocytopenic purpura: a case report and review of literature

Lee

Kim

Kwon

2018

Maxillofac Plast Reconstr Surg

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BackgroundPatients with chronic ITP (idiopathic thrombocytopenia) frequently do not require comprehensive medication for daily life. Usually, it had been regarded that postoperative bleeding after a simple or surgical extraction is easily controlled by simple local measures even in patients with ITP. This lack of regular medication usage can sometimes lead practitioners or patients to underestimate the potential life-threatening risk of ITP. There had been no report on postoperative hemorrhage in a patient with ITP related to dental implant surgery.Case presentationThis report presented a life-threatening postoperative hemorrhage after dental implant surgery in an adult with chronic ITP and subsequent emergency management after severe bleeding and airway compromise.ConclusionThe presented case emphasizes the thorough hematological evaluation of the patients even for patients who do not take any specific medications for asymptomatic, chronic ITP.

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Section: Discussionmentioning

confidence: 99%

Life-threating outcomes after dental implantation in patient with idiopathic thrombocytopenic purpura: a case report and review of literature

Lee

Kim

Kwon

2018

Maxillofac Plast Reconstr Surg

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Arteriovenous fistula for long-term venous access for boys with hemophilia

McCarthy

Valentino

Bonilla

et al. 2007

Journal of Vascular Surgery

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Modelling haemophilia epidemiology and treatment modalities to estimate the unconstrained factor VIII demand

et al. 2004

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The article presents a new method for estimating the unconstrained factor VIII (FVIII) demand based on the principles of decision analysis. Epidemiology and treatment modalities were integrated into a model for unconstrained FVIII demand. Assumptions for each variable with impact on the unconstrained FVIII demand were defined and probability estimates for these variables were obtained from the literature and medical experts. The sensitivity of the unconstrained FVIII demand to each of the variables was determined, and the variables with the greatest impact were modelled probabilistically. The probability-weighted average for the unconstrained FVIII demand model was 6.9 units per capita with a 90% uncertainty interval of 2.7-13.6 units per capita. When compared with FVIII usage in countries, only Luxembourg's use of FVIII (7.7 units per capita) exceeded the probability-weighted average for the modelled unconstrained FVIII demand. As better information becomes available, revision of model variables is easily accomplished allowing for a more accurate and dynamic forecast of demand over time. More accurate modelling of the 'true' demand longitudinally should help prevent shortages of FVIII concentrates such as those that have occurred in the past. In addition, a more accurate forecast of FVIII demand will allow national health care policy makers to better allocate financial and other resources. Sufficient and consistent supply of FVIII concentrates and appropriate financing of haemophilia care will allow the clinical benefits of more aggressive treatment regimens such as prophylaxis to be realized.

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Optimal treatment regimens for patients with bleeding disorders

Cited by 7 publications

References 35 publications

Life-threating outcomes after dental implantation in patient with idiopathic thrombocytopenic purpura: a case report and review of literature

Life-threating outcomes after dental implantation in patient with idiopathic thrombocytopenic purpura: a case report and review of literature

Arteriovenous fistula for long-term venous access for boys with hemophilia

Modelling haemophilia epidemiology and treatment modalities to estimate the unconstrained factor VIII demand

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