Optimal Treatment for Ocd (Oto): A Randomised Controlled Feasibility Trial Comparing the Clinical and Cost Effectiveness of Cognitive Behavioural Therapy (Cbt) and Selective Serotonin Reuptake Inhibitors (Ssri) and Their Combination in the Management of Obsessive Compulsive Disorder

Fineberg, NA; Baldwin, D.S.; Drummond, Lynne M.; Wyatt, Solange; Hanson, Jasmine; Gopi, Srinivas; Kaur, Sukhwinder; Reid, Jemma; Marwah,; Sachdev, Ricky A.; Pampaloni, Ilenia; Shahper, Sonia; Varlakova, Yana; Mpavaenda, Davis; Manson, Christopher; O'Leary, Cliodhna; Irvine, Karen; Monji-Patel, Deela; Shodunke, Ayotunde; Dyer, Tony; Dymond, Amy; Barton, Garry; Wellsted, David

doi:10.1016/j.euroneuro.2017.10.027

Cited by 5 publications

(5 citation statements)

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“…Since the publication of the APA guidelines for the treatment of OCD, more RCTs have been published confirming these positive findings. 24 - 26 A meta-analysis with high overall confidence according to the AMSTAR-2 criteria ( ) included 17 RCTs (n=3,097) and demonstrated that SSRIs are more effective than placebo in reducing OCD symptoms. 27 The overall relative risk for treatment response was 1.84 (95%CI 1.56-2.17) and the overall reduction in Y-BOCS scores against placebo was -3.21 (95%CI -3.84 to -2.57).…”

Section: Resultsmentioning

confidence: 99%

Brazilian Research Consortium on Obsessive-Compulsive Spectrum Disorders guidelines for the treatment of adult obsessive-compulsive disorder. Part I: pharmacological treatment

Oliveira¹,

Barros²,

Mathis³

et al. 2023

Brazilian Journal of Psychiatry

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Objectives: To summarize evidence-based pharmacological treatments and provide guidance on clinical interventions for adult patients with obsessive-compulsive disorder (OCD). Methods: The American Psychiatric Association (APA) guidelines for the treatment of OCD (2013) were updated with a systematic review assessing the efficacy of pharmacological treatments for adult OCD, comprising monotherapy with selective serotonin reuptake inhibitors (SSRIs), clomipramine, serotonin and norepinephrine reuptake inhibitors (SNRIs), and augmentation strategies with clomipramine, antipsychotics, and glutamate-modulating agents. We searched for the literature published from 2013-2020 in five databases, considering the design of the study, primary outcome measures, types of publication, and language. Selected articles had their quality assessed with validated tools. Treatment recommendations were classified according to levels of evidence developed by the American College of Cardiology and the American Heart Association (ACC/AHA). Results: We examined 57 new studies to update the 2013 APA guidelines. High-quality evidence supports SSRIs for first-line pharmacological treatment of OCD. Moreover, augmentation of SSRIs with antipsychotics (risperidone, aripiprazole) is the most evidence-based pharmacological intervention for SSRI-resistant OCD. Conclusion: SSRIs, in the highest recommended or tolerable doses for 8-12 weeks, remain the first-line treatment for adult OCD. Optimal augmentation strategies for SSRI-resistant OCD include low doses of risperidone or aripiprazole. Pharmacological treatments considered ineffective or potentially harmful, such as monotherapy with antipsychotics or augmentation with ketamine, lamotrigine, or N-acetylcysteine, have also been detailed.

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Section: Resultsmentioning

confidence: 99%

Brazilian Research Consortium on Obsessive-Compulsive Spectrum Disorders guidelines for the treatment of adult obsessive-compulsive disorder. Part I: pharmacological treatment

Oliveira¹,

Barros²,

Mathis³

et al. 2023

Brazilian Journal of Psychiatry

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“…Fourth, the fact that 11.43% of the participants dropped out during follow-up measurements may prevent definitive results on the effect of treatments. Although complete-case analysis is suitable for feasibility studies [64], this approach cannot consider the potential effect on missing participants. However, the dropout rate of this study is significantly lower than the mean rate reported in a recent systematic review and meta-analysis of dropout rates in digital interventions in patients with chronic diseases, including CVDs [65], where the overall dropout rate was 43% for observational studies and randomized control trials.…”

Section: Limitations and Future Researchmentioning

confidence: 99%

Effectiveness of Mindfulness and Positive Strengthening mHealth Interventions for the Promotion of Subjective Emotional Wellbeing and Management of Self-Efficacy for Chronic Cardiac Diseases

Tabernero

Gutiérrez‐Domingo

Steca

et al. 2022

JPM

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Intervention in health prevention and treatment via mobile phones is becoming a key element on health promotion. Testing the efficacy of these mobile health (mHealth) psychological interventions for cardiovascular health is necessary as it is a chronic pathology, and it can influence the affective and cognitive states of patients. This research aimed to analyze the effectiveness of two brief psychological interventions—mindfulness and positive strengthening—to promote subjective emotional wellbeing and disease management self-efficacy using mHealth. This was a three-arm intervention and feasibility study, with a pre-post design and three follow-up measures with 105 patients (93 completed all phases) with cardiovascular diseases. Group 1 and 2 received the mindfulness or strengthening intervention, and Group 3 was the control group. The positive–negative affect and management self-efficacy for chronic and cardiovascular diseases were analyzed over time, while anxiety and depression levels were assessed at the beginning of the study. The results showed that mindfulness and positive strengthening interventions both had a positive effect on participants’ affective state and management self-efficacy for the disease in comparison with the control group over time, even after controlling for baseline anxiety and depression levels. Positive strengthening seems to be more effective for improving cardiac self-efficacy, while mindfulness practice was significantly more effective at reducing negative affect at the first face-to-face evaluation.

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“…Evidence-based psychotherapy, including cognitive behavioural therapy (CBT) with exposure and response prevention and cognitive therapy elements, have been reported to be effective for many individuals with OCD [37]. However, although SSRIs' success rate is up to 60% [38], CBT's efficacy is routinely inconsistent between people. Even the combination of both treatment approaches only reaches up to 70% effectiveness [38].…”

Section: Treatments For Ocd and Music Therapymentioning

confidence: 99%

“…However, although SSRIs' success rate is up to 60% [38], CBT's efficacy is routinely inconsistent between people. Even the combination of both treatment approaches only reaches up to 70% effectiveness [38]. Thus, additional therapeutic approaches are needed.…”

Section: Treatments For Ocd and Music Therapymentioning

confidence: 99%

“…Generally, music therapy has shown positive impacts on people with mental health problems. As a catalyst of change, music therapy can reduce the symptoms of various disorders and foster overall well-being [38]. Some studies, for example, Atiwannapat et al [39], have found that individual or group music therapy, either active or receptive, as an adjunct to standard medication and psychological treatment, have some effect in reducing depressive scores in major depressive disorder (MDD) [40].…”

Section: Treatments For Ocd and Music Therapymentioning

confidence: 99%

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A Systematic Review of Scientific Studies and Case Reports on Music and Obsessive-Compulsive Disorder

Truong

Applewhite

Heiderscheit

et al. 2021

IJERPH

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Obsessive-compulsive disorder (OCD) is a severe psychiatric disorder, which can be associated with music-related symptoms. Music may also be used as an adjunct treatment for OCD. Following the PRISMA guidelines, we performed a systematic literature review exploring the relationship between music and OCD by using three online databases: PubMed, the Web of Science, and PsycINFO. The search terms were “obsessive compulsive disorder”, “OCD”, “music”, and “music therapy”. A total of 27 articles were utilised (n = 650 patients/study participants) and grouped into three categories. The first category comprised case reports of patients with musical obsessions in patients with OCD. Most patients were treated with selective serotonin reuptake inhibitors (SSRIs) or a combination of an SSRI and another pharmacological or a non-pharmacological treatment, with variable success. Studies on the music perception of people with OCD or obsessive-compulsive personality traits represented the second category. People with OCD or obsessive-compulsive personality traits seem to be more sensitive to tense music and were found to have an increased desire for harmony in music. Three small studies on music therapy in people with OCD constituted the third category. These studies suggest that patients with OCD might benefit from music therapy, which includes listening to music.

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Optimal Treatment for Ocd (Oto): A Randomised Controlled Feasibility Trial Comparing the Clinical and Cost Effectiveness of Cognitive Behavioural Therapy (Cbt) and Selective Serotonin Reuptake Inhibitors (Ssri) and Their Combination in the Management of Obsessive Compulsive Disorder

Cited by 5 publications

References 0 publications

Brazilian Research Consortium on Obsessive-Compulsive Spectrum Disorders guidelines for the treatment of adult obsessive-compulsive disorder. Part I: pharmacological treatment

Brazilian Research Consortium on Obsessive-Compulsive Spectrum Disorders guidelines for the treatment of adult obsessive-compulsive disorder. Part I: pharmacological treatment

Effectiveness of Mindfulness and Positive Strengthening mHealth Interventions for the Promotion of Subjective Emotional Wellbeing and Management of Self-Efficacy for Chronic Cardiac Diseases

A Systematic Review of Scientific Studies and Case Reports on Music and Obsessive-Compulsive Disorder

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