Optimal treatment conditions for low-intensity pulsed ultrasound therapy for Alzheimer’s disease: applications from mice to humans
Tomohiko Shindo,
Kumiko Eguchi,
Yuto Monma
et al.
Abstract:Purpose
We previously developed a novel therapy with low-intensity pulsed ultrasound (LIPUS) that ameliorates cognitive decline through upregulation of endothelial nitric oxide synthase (eNOS) in mouse models of Alzheimer’s disease (AD). In a randomized, double-blind, placebo-controlled pilot trial, we demonstrated that whole-brain LIPUS therapy is safe and tends to suppress the cognitive decline in early AD patients. We herein report the findings of our basic experiments that we performed for th… Show more
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