Optimal timing of pulse onset for language mapping with navigated repetitive transcranial magnetic stimulation

Krieg, Sandro M.; Tarapore, Phiroz E.; Picht, Thomas; Tanigawa, N; Houde, John F.; Sollmann, Nico; Meyer, Bernhard; Vajkoczy, Peter; Berger, Mitchel S.; Ringel, Florian; Nagarajan, Srikantan S.

doi:10.1016/j.neuroimage.2014.06.016

Cited by 94 publications

(79 citation statements)

References 77 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, we were particularly meticulous to avoid such unpleasantness; if the stimulation caused discomfort to the subject due to muscle contraction (in a short test session before the actual measurements), the stimulation intensity was lowered in decrements of 5–10% until it was tolerable. Moreover, the experimental setup has been validated by DCS, where discomfort due to scalp or muscle stimulation is not an issue, and found to match well with DCS particularly in ventral anterior areas (see e.g., Picht et al, 2013; Tarapore et al, 2013; Krieg et al, 2014). Consequently, the stimulation intensity varied somewhat across subjects (80–110% of the APB MT; 30–40% of the stimulator output).…”

Section: Methodsmentioning

confidence: 81%

See 1 more Smart Citation

Effects of navigated TMS on object and action naming

Hernandez-Pavon

Mäkelä

Lehtinen

et al. 2014

Front. Hum. Neurosci.

View full text Add to dashboard Cite

Transcranial magnetic stimulation (TMS) has been used to induce speech disturbances and to affect speech performance during different naming tasks. Lately, repetitive navigated TMS (nTMS) has been used for non-invasive mapping of cortical speech-related areas. Different naming tasks may give different information that can be useful for presurgical evaluation. We studied the sensitivity of object and action naming tasks to nTMS and compared the distributions of cortical sites where nTMS produced naming errors. Eight healthy subjects named pictures of objects and actions during repetitive nTMS delivered to semi-random left-hemispheric sites. Subject-validated image stacks were obtained in the baseline naming of all pictures before nTMS. Thereafter, nTMS pulse trains were delivered while the subjects were naming the images of objects or actions. The sessions were video-recorded for offline analysis. Naming during nTMS was compared with the baseline performance. The nTMS-induced naming errors were categorized by error type and location. nTMS produced no-response errors, phonological paraphasias, and semantic paraphasias. In seven out of eight subjects, nTMS produced more errors during object than action naming. Both intrasubject and intersubject analysis showed that object naming was significantly more sensitive to nTMS. When the number of errors was compared according to a given area, nTMS to postcentral gyrus induced more errors during object than action naming. Object naming is apparently more easily disrupted by TMS than action naming. Different stimulus types can be useful for locating different aspects of speech functions. This provides new possibilities in both basic and clinical research of cortical speech representations.

show abstract

Section: Methodsmentioning

confidence: 81%

“…The 0-ms onset produced more specific results in the parietal areas when compared to DCS data (Krieg et al, 2014). The 0-ms paradigm resembles more precisely the one applied in DCS so it is not surprising that the match between the 0-ms onset time and DCS is better.…”

Section: Discussionmentioning

confidence: 98%

Effects of navigated TMS on object and action naming

Hernandez-Pavon

Mäkelä

Lehtinen

et al. 2014

Front. Hum. Neurosci.

View full text Add to dashboard Cite

show abstract

“…The standard rTMS language mapping protocol was used, which has been published repeatedly in the past (Lioumis et al 2012;Picht et al 2013;Sollmann et al 2013b;Tarapore et al 2013;Krieg et al 2014b).…”

Section: Language Mapping By Rtmsmentioning

confidence: 99%

“…This was done randomly, and each site was stimulated three nonconsecutive times with a distance of approximately 10 mm between the two sites. As mentioned before, the mapping intensity and frequency were individually determined by using the current standard protocol (Pascual-Leone et al 1991;Sollmann et al 2013b;Sollmann et al 2013a;Tarapore et al 2013;Picht et al 2013;Krieg et al 2014b). The pictures were displayed for 700 ms (display time, DT) on the screen.…”

Section: Language Mapping By Rtmsmentioning

confidence: 99%

“…The picture-to-trigger interval (PTI), the time between the appearance of the displayed picture and the onset of the rTMS stimulation, was 300 ms in the first 15 patients and 0 ms in the following 22 patients, since there is evidence for the application of both PTIs (Salmelin et al 2000;Indefrey 2011;Rogic et al 2014;Wheat et al 2013;Tarapore et al 2013;Krieg et al 2014b). Nevertheless we decided to correct our protocol using a PTI of 0 ms regarding a recent examination of the advantages for rTMS language mapping (Krieg et al 2014b). The two consecutive baseline tests and the language mapping were recorded on video for later objective evaluation.…”

Section: Language Mapping By Rtmsmentioning

confidence: 99%

See 1 more Smart Citation

Visualization of subcortical language pathways by diffusion tensor imaging fiber tracking based on rTMS language mapping

Negwer

Ille

Hauck

et al. 2016

Brain Imaging and Behavior

Self Cite

View full text Add to dashboard Cite

Diffusion tensor imaging fiber tracking (DTI FT) is used to visualize subcortical fiber tracts. Yet, there is no standard at hand to visualize language-involved subcortical fibers reliably. Thus, this study investigates the feasibility of using language-related cortical areas identified via repetitive navigated transcranial magnetic stimulation (rTMS) to seed DTI FT of subcortical language tracts. From 2011 to 2014, 37 patients with left-hemispheric perisylvian lesions were examined. Language-positive rTMS stimulation spots were integrated in the deterministic tractography software (BrainLAB, iPlanNet 3.0) as objects and used as seed regions for DTI FT. Tractography was then performed in each patient with 77 different combinations of fiber lengths (40 - 100 mm) and fractional anisotropy (FA; 0.01 - 0.5). The rTMS-based DTI FT identified all commonly known subcortical language tracts, such as the corticonuclear tract, arcuate fascicle, uncinate fascicle, superior longitudinal fascicle, inferior longitudinal fascicle, arcuate fibers, commissural fibers, corticothalamic fibers, and the fronto-occipital fascicle. In 32 patients (86.5 %), each above-named tract could be visualized, while at least 6 out of these 9 tracts were identified in each patient. A fiber length of 100 mm and an FA of 0.1 or 0.15 provided optimal visualization by revealing 125 and 61 individually tracked fibers per visualized language tract and 90 % and 73 % of all language-related tracts, respectively. This study proves the feasibility of rTMS-based DTI FT for subcortical language tracts, provides suitable settings, and shows its easy and standardizable application for the visualization of every language tract in 86.5 % of patients.

show abstract

Language mapping with navigated transcranial magnetic stimulation in pediatric and adult patients undergoing epilepsy surgery: Comparison with extraoperative direct cortical stimulation

Lehtinen

Mäkelä

et al. 2018

Epilepsia Open

View full text Add to dashboard Cite

SummaryObjectiveNavigated transcranial magnetic stimulation (nTMS) is becoming increasingly popular in noninvasive preoperative language mapping, as its results correlate well enough with those obtained by direct cortical stimulation (DCS) during awake surgery in adult patients with tumor. Reports in the context of epilepsy surgery or extraoperative DCS in adults are, however, sparse, and validation of nTMS with DCS in children is lacking. Furthermore, little is known about the risk of inducing epileptic seizures with nTMS in pediatric epilepsy patients. We provide the largest validation study to date in an epilepsy surgery population.MethodsWe compared language mapping with nTMS and extraoperative DCS in 20 epilepsy surgery patients (age range 9‐32 years; 14 children and adolescents).ResultsIn comparison with DCS, sensitivity of nTMS was 68%, specificity 76%, positive predictive value 27%, and negative predictive value 95%. Age, location of ictal‐onset zone near or within DCS‐mapped language areas or severity of cognitive deficits had no significant effect on these values. None of our patients had seizures during nTMS.SignificanceOur study suggests that nTMS language mapping is clinically useful and safe in epilepsy surgery patients, including school‐aged children and patients with extensive cognitive dysfunction. Similar to in tumor surgery, mapping results in the frontal region are most reliable. False negative findings may be slightly more likely in epilepsy than in tumor surgery patients. Mapping results should always be verified by other methods in individual patients.

show abstract

Optimal timing of pulse onset for language mapping with navigated repetitive transcranial magnetic stimulation

Cited by 94 publications

References 77 publications

Effects of navigated TMS on object and action naming

Effects of navigated TMS on object and action naming

Visualization of subcortical language pathways by diffusion tensor imaging fiber tracking based on rTMS language mapping

Language mapping with navigated transcranial magnetic stimulation in pediatric and adult patients undergoing epilepsy surgery: Comparison with extraoperative direct cortical stimulation

Contact Info

Product

Resources

About