Optimal timing of antimicrobial prophylaxis before surgery: a review of recent evidence

Sathoo, Saarat; Thomas, Vimal; Kannan, Amudhan; Srinivasan, Anirudh

doi:10.17179/excli2021-4472

Cited by 1 publication

(1 citation statement)

References 5 publications

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“…The WHO recommends administering the antibiotic 30-60 minutes prior to the incision whereas the CDC recommends administering it at the time of the incision as prophylaxis for CS-related SSIs. 7,27 The American College of Obstetrics and Gynecology recommends antibiotic administration 60 minutes before the incision. 26 Administration of antibiotics 60 minutes prior to incision ensures optimal tissue levels of antibiotics at the surgical site.…”

Section: Discussionmentioning

confidence: 99%

The Impact of an Evidence-Based Bundle on Cesarean Section-Related Surgical Site Infections: A Randomized Clinical Trial

Gan,

Khursheed,

Savanur

et al. 2024

Maternal Fetal Med

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Objective To compare the effectiveness of an evidence-based bundle in minimizing cesarean section (CS)-related surgical site infections (SSIs) with that of standard routine care. Methods This was a single-center, parallel, and randomized clinical trial conducted at KAHER’s Dr. Prabhakar Kore Charitable Hospital, Belagavi, India, from January 2021 to December 31, 2021. Three hundred twenty women undergoing CS delivery were selected and allocated into two groups (1:1) using simple randomization with fixed allocation. An evidence-based surgical bundle (a combination of more than three perioperative interventions) was used for the interventional group, whereas the control group received routine standard perioperative care. The primary outcome was the incidence of SSI (superficial, deep, and organ or space SSIs) within 6 weeks postpartum in both groups. Categorical and continuous data were analyzed using appropriate statistical tests with a significance threshold set at P < 0.05. Results In this study, 16 and 17 participants each from the control and intervention groups, respectively, were lost to follow-up, resulting in a total of 144 and 143 study participants included in the respective groups. Twenty-eight (19.4%) and 14 (9.7%) women developed SSI in the control and intervention groups, respectively (P = 0.02). Methicillin-resistant Staphylococcus aureus was the most common cause of SSI in both groups (63.6% (7/11) and 100% (3/3) in the control and intervention groups, respectively). Conclusion The use of the evidence-based bundle for CS-related SSI prevention effectively decreased the incidence of SSI by half compared to standard routine practice. Implementing the use of this bundle in routine perioperative care will reduce the cost of CS and improve health outcomes in CSs. Trial registration Clinical Trials Registry-India (www.ctri.nic.in). Registration number: CTRI/2020/11/029246.

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Section: Discussionmentioning

confidence: 99%