Optimal synthesis conditions for NBF-modified 8,13-dihydroberberine derivatives

Zagrebaev, A. D.; Butova, V. V.; Guda, A. A.; Chapek, S. V.; Burov, O. N.; Kurbatov, S. V.; Vinyukova, E. Yu.; Neganova, M. E.; Aleksandrova, Yu. R.; Nikolaeva, N. S.; Demidov, O. P.; Soldatov, A. V.

doi:10.1039/d3nj04562e

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Optimal synthesis conditions for NBF-modified 8,13-dihydroberberine derivatives

Abstract: We developed a microfluidic synthesis with UV-Vis diagnostics using a 3D printed chip for 8,13-disubstituted berberines. This system yielded up to 30% higher product yields with high antioxidant activity compared to traditional batch synthesis.

Cited by 4 publications

References 97 publications

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