Optimal Strategies for Colorectal Cancer Screening

Jain, Shailavi; Maque, J.; Galoosian, Artin; Osuna-Garcia, Antonia; May, Folasade P.

doi:10.1007/s11864-022-00962-4

Cited by 44 publications

(33 citation statements)

References 71 publications

(70 reference statements)

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“…Colon cancer is one of the cancers with the highest prevalence in the world, its early clinical symptoms are not typical, and most of them are found in the late stage, so the mortality is high. [ 17 ] Although there are no guidelines to determine whether PLA patients should be routinely screened for colon cancer, many scholars believe that PLA is closely associated with colon cancer, especially in patients with Klebsiella pneumoniae infection and diabetes. [ 18 , 19 ] Mohan et al conducted a meta-analysis, which showed that patients with PLA had a much higher incidence of colon cancer than the general population, and over 90% of the pathogenic bacteria were Klebsiella pneumoniae.…”

Section: Discussionmentioning

confidence: 99%

Occult colon cancer with liver abscess and pancreatitis as the first manifestations: A case report

2023

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Introduction: Klebsiella pneumoniae-induced liver abscess (KP-PLA) is a common type of pyogenic liver abscess, severe acute pancreatitis (SAP) has high mortality, and poor prognosis in advanced colon cancer. There have been no report of SAP complicated with colon cancer after KP-PLA as so far. In this study, we reported a case of SAP secondary to KP-PLA with colon cancer for the first time, so as to provide reference for clinical diagnosis and treatment of these diseases.Patient concerns and diagnosis: A 64-year-old woman with a history of diabetes visited our hospital with abdominal pain for 5 + days. He was diagnosed with KP-PLA a month ago, which had not healed when he was admitted. He was diagnosed with SAP, and histological examination of colonic biopsy confirmed the diagnosis of moderately differentiated adenocarcinoma.Interventions and outcomes: He was treated with intravenous antibiotics and underwent modified endoscopic mucosal resection under colonoscopy. We conducted a 2-month follow-up, and there was no recurrence of liver abscess and pancreatitis. Conclusion:Screening for intestinal tumors is necessary in patients with cryptogenic liver abscess, especially KP-PLA with diabetes.

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Section: Discussionmentioning

confidence: 99%

Occult colon cancer with liver abscess and pancreatitis as the first manifestations: A case report

2023

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“…However, fecal DNA screening is costly, and some uncertainty as to whether further diagnostic tests are necessary when the result is positive but the follow-up colonoscopy is negative. 28 , 29 …”

Section: Discussionmentioning

confidence: 99%

Optimization of screening strategies for colorectal cancer based on fecal DNA and occult blood testing

Yao

Sun

Xiong

et al. 2023

European Journal of Public Health

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Background Fecal DNA and occult blood testing have been gradually developed for colorectal cancer (CRC) screening. Comparison of different testing strategies for these methods in CRC screening is in urgent need. This study aims to examine the efficacy of different testing strategies including multi-target fecal DNA testing, qualitative and quantitative fecal immunoassay tests (FITs). Methods Fecal samples were collected from patients diagnosed by colonoscopy. Tests using fecal DNA, quantitative FIT or qualitative FIT were performed on same fecal samples. Efficiency of different testing strategies within different populations was investigated. Results For high-risk populations (CRC and advanced adenoma), the positive rate of the three methods alone was 74.3–80%; the positive predictive values (PPVs) ranged from 37.3% to 77.8%, and the negative predictive values (NPVs) ranged from 86.3% to 92.2%. For combined testing strategies, the positive rate was 71.4–88.6%, PPVs ranged from 38.3% to 86.2%, and NPVs ranged from 89.6% to 92.9%. Parallel fecal multi-target DNA test and quantitative FIT appears to be superior when using a combined testing strategy. For the normal population, no significant difference was identified in efficacy between these methods when used alone and in combination. Conclusions Single testing strategy among the three methods is more suitable for the general population screening, and the combined testing strategy is more suitable for high-risk populations screening. The use of different combination strategies may have superiority in CRC high-risk population screening, but cannot conclude significant differences which may be attributed to the small sample size, large samples controlled trials are needed.

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“…CRC screening is more costeffective compared to the absence of screening programs 6 . Based on current scientific research, Fecal Immunochemical Testing (FIT) showed increased participation, has been recommended as the first option for CRC screening, and has a low cost 7 .…”

Section: Introductionmentioning

confidence: 99%

General Practitioners’ attitudes and beliefs on barriers to colorectal cancer screening: A qualitative study

Ploukou¹,

Birtsou²,

Gavana³

et al. 2023

Popul. Med.

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INTRODUCTIONColorectal cancer (CRC) is the third most frequent malignancy worldwide and causes millions of deaths every year. It is well known that more than 80% of colorectal cancers arise from adenomatous polyps, so screening for this cancer is effective for both early detection and prevention. Nevertheless, low rates of compliance are observed with the CRC screening recommendations. This study investigates the views and perceptions of General Practitioners (GPs) about CRC screening in Greece. METHODS We conducted semi-structured interviews with 32 GPs recruited from Central and Northern Greece. The interview guide addressed perceptions and barriers to colorectal cancer screening. Data collection took place between March 2019 and January 2020 and analyzed using Thematic Analysis. RESULTS GPs have a positive attitude toward CRC screening and try to exploit their opportunity during consultations to advise their patients about it. They face many barriers in their efforts to promote CRC screening. The most important of these are patients refusing for various reasons, lack of structures in the healthcare system or difficulties in approaching them, the cost of colonoscopy in the private sector, and concerns about the preparation or the process of the examination. CONCLUSIONS This study highlights the structural changes that are needed in the healthcare system, but also in the awareness of citizens and health professionals, in order to increase compliance with CRC screening.

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Optimal Strategies for Colorectal Cancer Screening

Cited by 44 publications

References 71 publications

Occult colon cancer with liver abscess and pancreatitis as the first manifestations: A case report

Occult colon cancer with liver abscess and pancreatitis as the first manifestations: A case report

Optimization of screening strategies for colorectal cancer based on fecal DNA and occult blood testing

General Practitioners’ attitudes and beliefs on barriers to colorectal cancer screening: A qualitative study

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