Optimal stimulation of Citrus reticulate for bioenergy extraction in MFCs and antioxidant activity via traditional Chinese medicine processing methods

Tsai, Po-Wei; Rogio, Kristian Gil G.; Hsieh, Cheng-Yang; Cruz, Kathlia A. De Castro; Lee, Chia-Jung; Hsueh, Chung-Chuan; Huang, Ting-Ning; Lu, Wei-Zhun; Xie, Zonglin; Jheng, Yong-Ni; Chen, Bor-Yann

doi:10.1016/j.jtice.2023.104690

Cited by 9 publications

(2 citation statements)

References 30 publications

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“…Studies reported that high levels of polyphenols are correlated with high antioxidant properties. This is due to the presence of double bonds within the aromatic ring and hydroxyl groups attached to the structure [38]. These structures enable polyphenols to decrease the rate of oxidation through deactivation of active radicals and their precursors.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant, Anti-Inflammatory and Antiproliferative Effects of Osmanthus fragrans (Thunb.) Lour. Flower Extracts

Huang,

Bueno,

Garcia

et al. 2023

Plants

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Osmanthus fragrans (Thunb.) Lour. flowers (OF-F) have been traditionally consumed as a functional food and utilized as folk medicine. This study evaluated the antioxidant, anti-inflammatory and cytotoxic effects of OF-F extracts on prostate cancer cells (DU-145) and determined possible protein-ligand interactions of its compounds in silico. The crude OF-F extracts—water (W) and ethanol (E) were tested for phytochemical screening, antioxidant, anti-inflammatory, and anti-cancer. Network and molecular docking analyses of chemical markers were executed to establish their application for anticancer drug development. OF-F-E possessed higher total polyphenols (233.360 ± 3.613 g/kg) and tannin (93.350 ± 1.003 g/kg) contents than OF-F-W. In addition, OF-F-E extract demonstrated effective DPPH scavenging activity (IC50 = 0.173 ± 0.004 kg/L) and contained a high FRAP value (830.620 ± 6.843 g Trolox/kg). In cell culture experiments, OF-F-E significantly reduced NO levels and inhibited cell proliferation of RAW-264.7 and DU-145 cell lines, respectively. Network analysis revealed O. fragrans (Thunb.) Lour. metabolites could affect thirteen molecular functions and thirteen biological processes in four cellular components. These metabolites inhibited key proteins of DU-145 prostate cancer using molecular docking with rutin owning the highest binding affinity with PIKR31 and AR. Hence, this study offered a new rationale for O. fragrans (Thunb.) Lour. metabolites as a medicinal herb for anticancer drug development.

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Section: Discussionmentioning

confidence: 99%

Antioxidant, Anti-Inflammatory and Antiproliferative Effects of Osmanthus fragrans (Thunb.) Lour. Flower Extracts

Huang,

Bueno,

Garcia

et al. 2023

Plants

Self Cite

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“…The quality of TCM mainly depends on two key factors, which are raw materials and processed drugs. Raw materials are the basis of quality, while the specific curative effect is determined by processing method (Tsai et al, 2023). The processing of TCM is a pharmaceutical technology based on the theory of TCM, syndrome differentiation, the inherent properties of drugs and the unique requirements for compounding and preparation.…”

Section: Tcm Processingmentioning

confidence: 99%

Integrating artificial intelligence into the modernization of traditional Chinese medicine industry: a review

Zhou,

Shen,

Hou

2024

Front. Pharmacol.

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Traditional Chinese medicine (TCM) is the practical experience and summary of the Chinese nation for thousands of years. It shows great potential in treating various chronic diseases, complex diseases and major infectious diseases, and has gradually attracted the attention of people all over the world. However, due to the complexity of prescription and action mechanism of TCM, the development of TCM industry is still in a relatively conservative stage. With the rise of artificial intelligence technology in various fields, many scholars began to apply artificial intelligence technology to traditional Chinese medicine industry and made remarkable progress. This paper comprehensively summarizes the important role of artificial intelligence in the development of traditional Chinese medicine industry from various aspects, including new drug discovery, data mining, quality standardization and industry technology of traditional Chinese medicine. The limitations of artificial intelligence in these applications are also emphasized, including the lack of pharmacological research, database quality problems and the challenges brought by human-computer interaction. Nevertheless, the development of artificial intelligence has brought new opportunities and innovations to the modernization of traditional Chinese medicine. Integrating artificial intelligence technology into the comprehensive application of Chinese medicine industry is expected to overcome the major problems faced by traditional Chinese medicine industry and further promote the modernization of the whole traditional Chinese medicine industry.

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Unveiling bioenergy-stimulating and electron-transporting characteristics of metabolites from Citrus microcarpa peels and pulps as medicated diet of sustainable energy resource

Tsai

Roxas

Tayo

et al. 2023

Biochemical Engineering Journal

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Optimal stimulation of Citrus reticulate for bioenergy extraction in MFCs and antioxidant activity via traditional Chinese medicine processing methods

Cited by 9 publications

References 30 publications

Antioxidant, Anti-Inflammatory and Antiproliferative Effects of Osmanthus fragrans (Thunb.) Lour. Flower Extracts

Antioxidant, Anti-Inflammatory and Antiproliferative Effects of Osmanthus fragrans (Thunb.) Lour. Flower Extracts

Integrating artificial intelligence into the modernization of traditional Chinese medicine industry: a review

Unveiling bioenergy-stimulating and electron-transporting characteristics of metabolites from Citrus microcarpa peels and pulps as medicated diet of sustainable energy resource

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