Optimal stimulation frequency for vibrational optical coherence elastography

Zhang, Duo; Wang, Jinjiang; Li, Chunhui; Huang, Zhihong

doi:10.1002/jbio.201960066

Cited by 6 publications

(3 citation statements)

References 29 publications

(34 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The potential of the common path approach has also been realized for the optical coherence elastography applications and benchtop [35][36][37] as well as fiber-based [38][39][40][41] common-path OCE systems have been reported. In clinical settings, fiber-based common path probes for elastography are preferred over their free space counterparts because of their lightweight and ease of handling.…”

Section: Introductionmentioning

confidence: 99%

Portable Optical Coherence Elastography System With Flexible and Phase Stable Common Path Optical Fiber Probe

Parmar

Sharma

et al. 2021

IEEE Access

View full text Add to dashboard Cite

Biomechanical properties drive the functioning of cells and tissue. Measurement of such properties in the clinic is quite challenging, however. Optical coherence elastography is an emerging technique in this field that can measure the biomechanical properties of the tissue. Unfortunately, such systems have been limited to benchtop configuration with limited clinical applications. A truly portable system with a flexible probe that could probe different sample sites with ease is still missing. In this work, we report a portable optical coherence elastography system based on a flexible common path optical fiber probe. The common path approach allows us to reduce the undesired phase noise in the system by an order of magnitude less than the standard non-common path systems. The flexible catheter makes it possible to probe different parts of the body with ease. Being portable, our system can be easily transported to and from the clinic. We tested the efficacy of the system by measuring the mechanical properties of the agarbased tissue phantoms. We also measured the mechanical properties (Young's Modulus) of the human skin at different sites. The measured values for the agar phantom and the skin were found to be comparable with the previously reported studies. Ultra-high phase stability and flexibility of the probe along with the portability of the whole system makes an ideal combination for the faster clinical adoption of the optical coherence elastography technique.

show abstract

Section: Introductionmentioning

confidence: 99%

Portable Optical Coherence Elastography System With Flexible and Phase Stable Common Path Optical Fiber Probe

Parmar

Sharma

et al. 2021

IEEE Access

View full text Add to dashboard Cite

show abstract

“…; Agilent Technologies, Santa Clara, CA 95051, USA) and a power amplifier (7724 DC-enabled AC power amplifier; AE Techron, Elkhart, IN 46516, USA) directly with a sinusoidal wave input signal to generate periodic stimulation to the sample. Based on the previous work carried out by our research group regarding the optimal stimulation frequency for vibrational OCE [26], the input sinusoidal signal was set at 650 Hz with a peak-to-peak amplitude of 30 milli-volts, which resulted in a vibration amplitude of 150-250 nm. The vibration amplitude was transmitted from the shaker to the sample and reference material via a solid-sample holder plate; the vibration amplitude was assumed to be uniformly distributed both in the sample and reference material layers.…”

Section: Oct/oce System Configuration and Imaging Protocolmentioning

confidence: 99%

Quantitative Tissue Elasticity Measurement of Human Cadaver Oesophagus by Using Vibrational Optical Coherence Elastography

Wang

Boga

et al. 2023

Applied Sciences

Self Cite

View full text Add to dashboard Cite

The mechanical properties and structure alteration (e.g., layer morphology and thickness) of the oesophagus wall can reflect its pathological conditions. Hence, quantitative measurement of the above-mentioned properties can play a significant role in aiding the disease diagnosis in clinical application. As a fast and non-invasive imaging modality, Optical coherence tomography (OCT) and vibrational elastography can provide high resolution (<10 µm) structural and mechanical mapping of soft tissue. This study is a preliminary study to explore the potential of OCT and VOCE to evaluate both structural and mechanical properties of the oesophagus wall. Jn total, 52 oesophageal tissue samples were acquired from seven human Thiel-embalmed cadavers and were examined by the vibrational OCE. Both the OCT structure image and quantitative elasticity of each sample layer were obtained. In the OCT structure image, the averaged thickness for each sample layer was measured and corresponded with the histological image. Lamina propria has the largest thickness of 158.14 ± 8.75 µm, submucosa is the thinnest with a thickness of 143.19 ± 10.11 µm, and the thickness of muscularis mucosa is 149.49 ± 10.85 µm. Averaged intensity of back-scattered light from each sample layer was evaluated. Intensity of lamina propria layer, muscularis mucosa layer, and submucosa layer have an average value of 79.27 ± 0.51 dB, 69.83 ± 0.56 dB, and 76.10 ± 0.55 dB, respectively. The quantitative elasticity of each sample layer was evaluated in OCE. Elasticity of the lamina propria layer, muscularis mucosa layer, and submucosa layer were estimated as 115.64 ± 8.80 kPa, 60.28 ± 5.27 kPa, and 205.25 ± 19.03 kPa, respectively. The quantitative elasticity results obtained by vibrational OCE corresponded with the collagen distribution trend in each sample layer. This study demonstrates the ability of OCT and vibrational OCE in the characterisation and quantitative evaluation of human cadaver oesophagus wall-structure properties and mechanical properties. The feasibility of applying OCT and vibrational OCE in clinical diagnosis of oesophageal disease is also discussed.

show abstract

“…As can be seen in the aforementioned examples, quasi-static compression OCE, mostly phase-sensitive with some sort of compliance layer as stress sensor, is currently the most advanced OCE method. In the last few years, other approaches rose to the horizon of feasibility, e.g., vibrational OCE, 311,312 which uses OCT to record the reaction of a sample to a variation of vibration frequencies. With this, a 3D resonant frequency map of the sample can be generated and viscoelastic behavior can be investigated.…”

Section: Optical Coherence Elastography: Depth Resolved Optical Palpationmentioning

confidence: 99%

Enhanced medical diagnosis for dOCTors: a perspective of optical coherence tomography

et al. 2021

View full text Add to dashboard Cite

Significance: After three decades, more than 75,000 publications, tens of companies being involved in its commercialization, and a global market perspective of about USD 1.5 billion in 2023, optical coherence tomography (OCT) has become one of the fastest successfully translated imaging techniques with substantial clinical and economic impacts and acceptance.Aim: Our perspective focuses on disruptive forward-looking innovations and key technologies to further boost OCT performance and therefore enable significantly enhanced medical diagnosis.Approach: A comprehensive review of state-of-the-art accomplishments in OCT has been performed. Results:The most disruptive future OCT innovations include imaging resolution and speed (single-beam raster scanning versus parallelization) improvement, new implementations for dual modality or even multimodality systems, and using endogenous or exogenous contrast in these hybrid OCT systems targeting molecular and metabolic imaging. Aside from OCT angiography, no other functional or contrast enhancing OCT extension has accomplished comparable clinical and commercial impacts. Some more recently developed extensions, e.g., optical coherence elastography, dynamic contrast OCT, optoretinography, and artificial intelligence enhanced OCT are also considered with high potential for the future. In addition, OCT miniaturization for portable, compact, handheld, and/or cost-effective capsule-based OCT applications, home-OCT, and self-OCT systems based on micro-optic assemblies or photonic integrated circuits will revolutionize new applications and availability in the near future. Finally, clinical translation of OCT including medical device regulatory challenges will continue to be absolutely essential.Conclusions: With its exquisite non-invasive, micrometer resolution depth sectioning capability, OCT has especially revolutionized ophthalmic diagnosis and hence is the fastest adopted imaging technology in the history of ophthalmology. Nonetheless, OCT has not been completely exploited and has substantial growth potential-in academics as well as in industry. This applies not only to the ophthalmic application field, but also especially to the original motivation of OCT to enable optical biopsy, i.e., the in situ imaging of tissue microstructure with a resolution approaching that of histology but without the need for tissue excision.

show abstract

Optimal stimulation frequency for vibrational optical coherence elastography

Cited by 6 publications

References 29 publications

Portable Optical Coherence Elastography System With Flexible and Phase Stable Common Path Optical Fiber Probe

Portable Optical Coherence Elastography System With Flexible and Phase Stable Common Path Optical Fiber Probe

Quantitative Tissue Elasticity Measurement of Human Cadaver Oesophagus by Using Vibrational Optical Coherence Elastography

Enhanced medical diagnosis for dOCTors: a perspective of optical coherence tomography

Contact Info

Product

Resources

About