Optimal Skeletal Muscle Mass Index Cut-Off Values for Presarcopenia Evaluated by Computed Tomography against Dual-Energy X-ray Absorptiometry in Patients with Chronic Liver Disease

Abstract

Although dual-energy X-ray absorptiometry (DXA) and body impedance analysis are commonly used to measure skeletal muscle mass (SMM), a computed tomography (CT) scan is preferred in clinical practice. We aimed to propose the cut-off values of skeletal muscle mass index (SMI) calculated using CT scans, using DXA as the reference method. We retrospectively assessed 589 patients with chronic liver disease. The SMI was assessed using appendicular SMM by DXA and total muscle area at the level of the third lumbar vertebra (L3) calculated by CT. The cut-off value was determined with reference to the Asian Working Group for Sarcopenia criteria. DXA identified 251 (42.6%) patients as having presarcopenia. In men, the cut-off value of SMI for presarcopenia was determined to be 45.471 cm2/m2, with an area under the curve (AUC) of 0.863 (95% confidence interval (CI): 0.823 to 0.903), and in women, this value was determined to be 35.170 cm2/m2, with an AUC of 0.846 (95% CI: 0.800 to 0.892). Cohen’s kappa coefficient was 0.575 (95% CI: 0.485–0.665) in men and 0.539 (95% CI: 0.438–0.639) in women.

Impact of skeletal muscle mass on postoperative complications in oral cancer surgery

“…( 2 )). The optimal cut-off value for L3SMI was reported by Ohashi et al [ 22 ] (men: 45.471 cm 2 /m 2 , women: 35.170 cm 2 /m 2 ). This cut-off value correlated with the value from DXA, which is used to diagnose low skeletal muscle mass as defined by the Asian Working Group for Sarcopenia (AWGS) [ 23 ].…”

Association of postoperative adverse events with low skeletal muscle mass measured from the 12th thoracic vertebral skeletal muscle mass in oral cancer patients

“…( 2)]. The optimal cut-off value for L3SMI was reported by Ohashi et al [22] (men: 45.471 cm 2 /m 2 women: 35.170 cm 2 /m 2 ). This cut-off value correlated with the value from DXA, which is used to diagnose low skeletal muscle mass as de ned by the Asian Working Group for Sarcopenia (AWGS) [23].…”

A Case of Acromegaly With Progressed Diabetic Retinopathy and Sarcopenia Diagnosed Following the Onset of Severe Hypoglycemia

“…His medication was already stopped for several days at the previous hospital. Grip strength (5.9 kg and 5.8 kg at right and left; <26 kg), walking speed (0.45 m/sec; ≤0.8 m/sec), and skeletal muscle index (SMI) at the third lumbar vertebra level in a computed tomography (CT) image-calculated area (29.4 cm 2 /m 2 ; ≤42.0 cm 2 /m 2 ) suggested apparent sarcopenia (Figure 1) [13,14].…”