The Cauchy problem for the Hardy-Hénon parabolic equation is studied in the critical and subcritical regime in weighted Lebesgue spaces on the Euclidean space R d . Well-posedness for singular initial data and existence of nonradial forward self-similar solution of the problem are previously shown only for the Hardy and Fujita cases (γ ≤ 0 ) in earlier works. The weighted spaces enable us to treat the potential |x| γ as an increase or decrease of the weight, thereby we can prove well-posedness to the problem for all γ with − min{2, d} < γ including the Hénon case (γ > 0 ). As a byproduct of the well-posedness, the self-similar solutions to the problem are also constructed for all γ without restrictions. A nonexistence result of local solution for supercritical data is also shown. Therefore our critical exponent s c turns out to be optimal in regards to the solvability.