In this paper, we study the impact of the co-channel interference (CCI) in conjunction with the impact of residual self-interference (SI) on the end-to-end (E2E) performance of a denoise-and-forward full-duplex one-way relay channel (DNF-FD-OWRC) network. The investigated system comprises one source node S, which communicates with one destination node D with the aid of an FD relay node, over Rayleigh fading channels. Closed-form expressions for the cumulative distribution function (CDF) and the distribution of the E2E signal-to-interference and noise ratio (SINR) are derived and presented. Moreover, a closedform expression for the E2E outage probability is presented and validated using Monte Carlo simulations. The obtained results demonstrate the impact of the residual SI and CCI on the E2E performance of the DNF-FD-OWRC and demonstrate the ability of DNF-OWRC to improve the throughput of a conventional half-duplex (HD) OWRC.Index Terms-co-channel interference (CCI), self-interference (SI), denoise-and-forward full-duplex one-way relay channel (DNF-FD-OWRC), end-to-end (E2E), cumulative distribution function (CDF), signal-to-interference and noise ratio (SINR), half-duplex (HD)