Oxidative coupling of methane (OCM) is a complex surface catalysis and gas‐phase reaction process to transform methane into ethane, ethylene and higher molecular weight hydrocarbons (C2+). However, the C2+ product yields in single‐pass fixed‐bed reactors have been limited by the intrusion of gas‐phase combustion reactions. To remedy this problem, a dual‐bed OCM reactor configuration was explored in which the O2 feed was distributed between two sequential packed bed reactors with interstage cooling using La2O3–CeO2 nanofiber fabric catalysts. At the overall CH4/O2 feed ratio of 4.0, the dual‐bed reactor configuration with split O2 introduction resulted in the ultimate C2+ product yield of 21%, which is significantly higher than the 16% observed in the single‐bed OCM reactor. In addition, spatially resolved species concentration and temperature profiles along the entire length of the dual‐bed reactor were also acquired by using in situ microprobe sampling.