Optimal maintenance treatment with calcipotriol/betamethasone dipropionate gel in Korean patients with psoriasis vulgaris: a multicentre randomized, controlled clinical trial

Lee, J.-H.; Park, Chul Jong; Kim, T.-Y.; Choe, Yong Beom; Kim, N.-I.; Song, Hae Jun; Youn, Jai Il; Youn, Sang Woong; Choi, Jee Ho; Kim, K.-J.

doi:10.1111/jdv.13865

Cited by 8 publications

(10 citation statements)

References 12 publications

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“…Additionally, 22 papers were obtained from LEO Pharma (Figure 1). Twenty‐five publications were included in the systematic review 13‐37 …”

Section: Resultsmentioning

confidence: 99%

“…Of those that did, two RCTs found that more versus less frequent application of Cal/BD was more efficacious. In a study of Korean patients, treatment with Cal/BD using a continuous daily regimen or an ‘as needed’ daily regimen were similarly efficacious, whereas a twice‐weekly regimen was significantly less efficacious than either of these regimens 25 . A twice‐weekly regimen was more efficacious than a once‐weekly regimen of Cal/BD in a study of Chinese patients, with no difference noted between the twice‐weekly regimen and a group randomized to once‐daily Cal 36…”

Section: Resultsmentioning

confidence: 99%

“…In a study of Korean patients, treatment with Cal/BD using a continuous daily regimen or an 'as needed' daily regimen were similarly efficacious, whereas a twice-weekly regimen was significantly less efficacious than either of these regimens. 25 A twice-weekly regimen was more efficacious than a once-weekly regimen of Cal/BD in a study of Chinese patients, with no difference noted between the twice-weekly regimen and a group randomized to once-daily Cal. 36 For scalp psoriasis, following complete remission, twice-weekly application versus on-demand treatment of Cal/BD gel was more effective and was associated with a lower rate of relapse; however, the frequency of 'on demand' application was not reported.…”

Section: Treatment Regimensmentioning

confidence: 95%

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Systematic review and practical guidance on the use of topical calcipotriol and topical calcipotriol with betamethasone dipropionate as long‐term therapy for mild‐to‐moderate plaque psoriasis

Zhao

Asahina

Asawanonda

et al. 2021

The Journal of Dermatology

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While many patients with psoriasis are candidates for topical agents, long‐term treatment effects are unclear. This systematic review evaluated global findings from clinical trials and real‐world studies of topical calcipotriol and the two‐compound formulation of calcipotriol and betamethasone dipropionate for mild‐to‐moderate plaque psoriasis (including scalp psoriasis). PubMed, Embase and MEDLINE were searched for relevant English‐language publications along with Chinese, Japanese, Korean and Latin American publication databases. Identified articles were screened by title and abstract against predefined inclusion/exclusion criteria. A narrative synthesis of key efficacy and safety findings from the full papers of selected publications was developed. Thirty‐seven relevant papers were identified (25 English, 11 Chinese and one Japanese‐language study) including 28 randomized controlled trials. While there was significant heterogeneity in study length, treatment intensity and clinical measures, following a critical review of the published data combined with expert opinion, the following clinical practice recommendations were agreed in order to assist healthcare providers: in adults, long‐term treatment with calcipotriol/betamethasone dipropionate is well tolerated and efficacious for up to 1 year on an ‘as needed’ basis, and for up to 16 weeks on a fixed‐treatment regimen. Calcipotriol is also well tolerated and efficacious when used long term (up to 52 weeks) ‘as needed’ and for up to 20 weeks on a fixed‐treatment regimen. Used on an ‘as needed’ basis for up to 1 year, the safety and efficacy profile of fixed‐dose combination calcipotriol/betamethasone dipropionate is more favorable than calcipotriol alone; regular consultation between patients and their dermatologist/primary care physician is required to review psoriasis symptoms and adjust treatment accordingly; a specific treatment goal should be agreed on initiation of topical agent(s) to determine when long‐term treatment can begin or if a regimen change is warranted; and application frequency during the continued treatment phase should consider the patients’ treatment expectations and goals.

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“…Additionally, 22 papers were obtained from LEO Pharma (Figure 1). Twenty‐five publications were included in the systematic review 13‐37 …”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Treatment Regimensmentioning

confidence: 95%

See 1 more Smart Citation

Systematic review and practical guidance on the use of topical calcipotriol and topical calcipotriol with betamethasone dipropionate as long‐term therapy for mild‐to‐moderate plaque psoriasis

Zhao

Asahina

Asawanonda

et al. 2021

The Journal of Dermatology

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“…The twice‐weekly Cal/BD maintenance regimen provided comparable efficacy as daily treatment with calcipotriol, and both regimens were significantly more effective than once weekly Cal/BD ointment. Patients with limb or trunk PsO who achieved disease control after 8 weeks of daily treatment with Cal/BD gel were randomized to either maintain once daily treatment continuously or as needed, or to twice weekly treatment on weekends for a further 8 weeks in a small Korean study 35 . Long‐term daily treatment used either continuously or as‐needed was significantly more effective at maintaining remission than weekend‐only therapy.…”

Section: What Different Topical Maintenance Therapy Regimens Exist?mentioning

confidence: 99%

“…The authors suggest that maintenance therapy should begin when a clinical response is reached, likely after approximately 4 weeks of acute topical treatment. A 4‐week acute treatment period has been used successfully in a scalp PsO maintenance study 32 and in the PSO‐LONG proactive maintenance study of Cal/BD foam, 7 while other studies have used induction phases as short as 2 weeks 37,38 or as long at 8 weeks 35 . Overall, 4 weeks of acute treatment is likely realistic for most patients, but decisions should be individualized since some patients may benefit from earlier or later transition from acute to maintenance therapy.…”

Section: Unanswered Questionsmentioning

confidence: 99%

Emerging paradigm shift toward proactive topical treatment of psoriasis: A narrative review

Papp

Dhadwal

Gooderham

et al. 2021

Dermatologic Therapy

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Psoriasis (PsO) requires safe and effective long-term management to reduce the risk of recurrence and decrease the frequency of relapse. Topical PsO therapies are a cornerstone in the management of PsO though safety concerns limit the chronic, continuous use of topical corticosteroids and/or vitamin D 3 analogs. Evidence-based guidelines on optimal treatment targets and maintenance therapy regimens are currently lacking. This review explores the evidence supporting approaches to maintenance topical therapy for PsO including continuous long-term therapy, chronic intermittent use, step-down therapy, sequential or pulse therapy regimens, and proactive maintenance therapy. Several unaddressed questions are discussed including how and when to transition from acute to maintenance therapy, strategies for monitoring long-term treatment, the role of topical maintenance therapy in the context of systemic and biologic therapies, risks of maintenance therapy, prescribing a topical preparation suitable for patients' preferences and skin type, and key concepts for patient education to maximize long-term outcomes. Overall, emerging evidence supports a paradigm shift toward proactive treatment once skin is completely clear as a strategy to enhance disease control without compromising safety.

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Vitamins, Amino Acids and Drugs and Formulations Used in Nutrition

Singleton¹,

Landry²,

Sirohi³

et al. 2018

Side Effects of Drugs Annual

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Optimal maintenance treatment with calcipotriol/betamethasone dipropionate gel in Korean patients with psoriasis vulgaris: a multicentre randomized, controlled clinical trial

Cited by 8 publications

References 12 publications

Systematic review and practical guidance on the use of topical calcipotriol and topical calcipotriol with betamethasone dipropionate as long‐term therapy for mild‐to‐moderate plaque psoriasis

Systematic review and practical guidance on the use of topical calcipotriol and topical calcipotriol with betamethasone dipropionate as long‐term therapy for mild‐to‐moderate plaque psoriasis

Emerging paradigm shift toward proactive topical treatment of psoriasis: A narrative review

Vitamins, Amino Acids and Drugs and Formulations Used in Nutrition

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