Optimal life stage for radiation sterilization of <i>Anopheles</i> males and their fitness for release

Andreasen, Margit; Curtis, C. F.

doi:10.1111/j.1365-2915.2005.00565.x

Cited by 74 publications

(77 citation statements)

References 27 publications

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“…25,26 However, the use of radiation imposes several undesirable limitations, including logistical issues, and the somatic damage unavoidably caused by the sterilising dose of radiation used. [27][28][29][30] Several field trials using radiation-or chemo-sterilised mosquitoes have been conducted, with some success, but there are also problems including poor performance of irradiated mosquitoes. 31 the radiation doses used induce dominant lethal mutations in the irradiated sperm such that most eggs die after being fertilised by such sperm.…”

Section: Population Suppression Strategiessterile Malesmentioning

confidence: 99%

Genetic control ofAedesmosquitoes

Alphey

McKemey

Nimmo

et al. 2013

Pathogens and Global Health

133

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Aedes mosquitoes include important vector species such as Aedes aegypti, the major vector of dengue. Genetic control methods are being developed for several of these species, stimulated by an urgent need owing to the poor effectiveness of current methods combined with an increase in chemical pesticide resistance. In this review we discuss the various genetic strategies that have been proposed, their present status, and future prospects. We focus particularly on those methods that are already being tested in the field, including RIDL and Wolbachia-based approaches.

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Section: Population Suppression Strategiessterile Malesmentioning

confidence: 99%

Genetic control ofAedesmosquitoes

Alphey

McKemey

Nimmo

et al. 2013

Pathogens and Global Health

133

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“…The irradiation of Anopheles albimanus male pupae aged Ͻ24 h by Ali and Rozenboom (1972) demonstrated that the males maintained the capacity of inseminating the females at all the x-ray doses tested (20 Ð 80 Gy). Sterilization by radiation is known to have less deleterious effects on Anopheles males when applied on adults rather than on pupae (Andreasen and Curtis 2005); however, Helinski et al (2006) found no statistically signiÞcant differences between Anopheles arabiensis males irradiated as old pupae or adults. It has been demonstrated that the age of the pupae when exposed to ␥ rays strongly affects their sensitivity to radiation in terms of somatic damages and residual fertility.…”

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confidence: 98%

γ Ray Dosimetry and Mating Capacity Studies in the Laboratory on <I>Aedes albopictus</I> Males

Balestrino

Medici

Candini

et al. 2010

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In Italy, Aedes albopictus Skuse is currently recognized as the most dangerous mosquito, and as currently applied conventional control methods gave unsatisfactory results, we are developing alternative strategies such as the sterile insect technique. To find the optimal sterilizing dose, male pupae were exposed to different doses of gamma rays in the range 20-80 Gy, generated by a Cesium-137 source. The effects of male pupal age at irradiation and gamma ray dose on adult male emergence, sterility level, longevity, and mating capacity were evaluated, and dose-response curves of residual fertility were calculated. Radiation tests were also performed on female pupae to observe their reproductive capacity in case of accidental release. Results confirmed that the age at which the male pupa is irradiated is an important factor that affects the longevity of the adult, whereas the effect of age on the induced sterility level is less pronounced. When male pupae older than 30 h were irradiated, the longevity of the adults was not affected by doses up to 40 Gy. The 40-Gy dose appeared sufficient to induce high level of sterility (>99%) at any male pupal age for all the strains tested. The duration of coupling and the number of mated females per male appeared to be affected by the radiation received by male pupae only at doses higher than 40 Gy. The female pupae were more sensitive to radiation than male pupae, with strong reduction in fecundity and fertility at 20 Gy and complete suppression of oviposition at higher doses.

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“…The sterile insect technique (SIT), which releases sterile (irradiated) male insects that mate with wild females, resulting in no progeny, has been used successfully for Ͼ50 years for control and eradication of several pests and disease vectors (3,4). However, irradiated mosquitoes have difficulty competing with wild males for wild females (5)(6)(7) and there are no large-scale SIT mosquito programs currently in operation. A proposed alternative approach that is also environmentally benign is the release of insects carrying a dominant lethal (RIDL) strategy.…”

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confidence: 99%

Analyzing the control of mosquito-borne diseases by a dominant lethal genetic system

Atkinson¹,

Zheng²,

Alphey

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

121

115

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Motivated by the failure of current methods to control dengue fever, we formulate a mathematical model to assess the impact on the spread of a mosquito-borne viral disease of a strategy that releases adult male insects homozygous for a dominant, repressible, lethal genetic trait. A dynamic model for the female adult mosquito population, which incorporates the competition for female mating between released mosquitoes and wild mosquitoes, density-dependent competition during the larval stage, and realization of the lethal trait either before or after the larval stage, is embedded into a susceptible-exposed-infectious-susceptible human-vector epidemic model for the spread of the disease. For the special case in which the number of released mosquitoes is maintained in a fixed proportion to the number of adult female mosquitoes at each point in time, we derive mathematical formulas for the disease eradication condition and the approximate number of released mosquitoes necessary for eradication. Numerical results using data for dengue fever suggest that the proportional policy outperforms a release policy in which the released mosquito population is held constant, and that eradication in Ϸ1 year is feasible for affected human populations on the order of 10 5 to 10 6 , although the logistical considerations are daunting. We also construct a policy that achieves an exponential decay in the female mosquito population; this policy releases approximately the same number of mosquitoes as the proportional policy but achieves eradication nearly twice as fast.dengue fever ͉ genetically modified mosquitoes ͉ mathematical epidemiology W orldwide morbidity and mortality from mosquito-borne viral diseases are substantial and on the rise (1). No licensed vaccine exists for the most important of these viruses, the dengue virus, which each year causes 50-100 million cases of dengue fever and 250,000-500,000 cases of the potentially fatal dengue hemorrhagic fever (2). The Aedes aegypti mosquito (also known as Stegomyia aegypti), which is the main vector for dengue fever and yellow fever, is endemic in the southeastern U.S., and the West Nile virus spread easily through the U.S. in recent years, suggesting the U.S. could be vulnerable in coming years to both natural and deliberate outbreaks of mosquito-borne viral diseases. Given the failure of current methods to control the spread of these diseases, considerable effort has gone into novel population-suppression strategies. The sterile insect technique (SIT), which releases sterile (irradiated) male insects that mate with wild females, resulting in no progeny, has been used successfully for Ͼ50 years for control and eradication of several pests and disease vectors (3, 4). However, irradiated mosquitoes have difficulty competing with wild males for wild females (5-7) and there are no large-scale SIT mosquito programs currently in operation. A proposed alternative approach that is also environmentally benign is the release of insects carrying a dominant lethal (RIDL) strategy. In this ap...

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Optimal life stage for radiation sterilization of Anopheles males and their fitness for release

Cited by 74 publications

References 27 publications

Genetic control ofAedesmosquitoes

Genetic control ofAedesmosquitoes

γ Ray Dosimetry and Mating Capacity Studies in the Laboratory on <I>Aedes albopictus</I> Males

Analyzing the control of mosquito-borne diseases by a dominant lethal genetic system

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