Optimal level of zinc supplementation for young rats fed rapeseed protein concentrate

Carbohydrate metabolism in erythrocytes of copper deficient rats11Publication # 538 of the Bureau of Nutritional Sciences.

“…1 and 2). The other rates were calculated as previously described [29] using the following equation: J 3 ϭ 3 ϫ J 5 , J 4 ϭ 2 ϫ J 5 , J 5 (see above), J 6 ϭ (J 1 or J 2 ) Ϫ J 5 , J 7 ϭ 2 ϫ (J 1 or J 2 ) Ϫ J 5 , J 8 ϭ J 7 ϫ v 2,3-dPGA /v C2-lactose ,J 9 ϭJ 7 ϪJ 8 , and J 10 ϭ v C2-lactate ϩ v C3-lactate . Abbreviations as follows: glucose (glc), fructose (fru), pentose phosphate pathway (PPP), fructose 6-phosphate (F6P), glyceraldehyde 3-phosphate (Gald3P), phosphofructokinase (PFK), 2,3-diphosphoglyceric acid (2,3-diPGA), phosphoglycerate kinase (PGK), lactate dehydrogenase (LDH).…”

“…The ash was dissolved in 2.9 mol/L hydrochloric acid and analyzed for copper by flame atomic absorption spectrophotometry [29] using a Perkin Elmer 5100PC (PerkinElmer Corporation, Norwalk, CT). Analytical standards were prepared from certified single-element stock solutions (SPEX Chemical, Metuchen, NJ).…”

Canola and Rapeseed

“…A 300 ppm dietary Zn was necessary to prevent the reduction in food consumption, weight gain, and plasma Zn levels caused by 20.0% rapeseed flour. Shah et al (1976Shah et al ( , 1979Shah et al ( , 1980) also observed Zn deficiency in rats feed rapeseed protein concentrate at 20.0% protein level; however, a lower level ofZn supplementation (150 ppm in the diet or 70 Jlg/ ml in the drinking water) was found sufficient to overcome the Zn deficiency symptoms.…”

Brain-Delivery of Zinc-Ions as Potential Treatment for Neurological Diseases: Mini Review

“…While control mice and rats are normally fed diets containing between 25 mg kg and 80 mg/kg Zn 2+ [95–101], Zn 2+ deficiency is caused when the diet contains 0.5 mg/kg – 6 mg/kg Zn 2+ [95, 99, 101]. Zn 2+ overdoses can be reached at 100 mg/kg – 180 mg/kg [96, 97]. However, though Zn 2+ overdoses might elevate serum Zn 2+ levels, this doesn’t necessarily lead to elevated brain Zn 2+ levels in healthy control animals.…”

“…Based on several studies [95, 96, 98, 99, 105, 111–116], we calculated the change in Zn 2+ levels based on measurements of serum and hepatic Zn 2+ levels in rats treated for 28–42 days with dietary zinc deficiency versus Zn 2+ supplementation. Our results revealed a steep increase in serum Zn 2+ levels that can be observed in response to very low levels of dietary Zn 2+ (0.57% dietary Zn 2+ compared to controls with 21.9% serum Zn 2+ levels and 6.8% dietary Zn 2+ compared to controls with 70% serum Zn 2+ levels of control animals) and milder Zn 2+ deficiency (20% dietary Zn 2+ compared to controls with 88% serum Zn 2+ levels of control animals) Fig.…”