Optimal Feature Selection from High-dimensional Fusion of Blood Smear Images for Leukemia Diagnosis

Abstract

The goal of this study is to improve blood smear image-based blood cancer prediction through medical diagnostic advancements. Blood cancers, particularly leukemia, are challenging to diagnose because of the complexity of biological data and the dimensionality of medical images. There are interpretability and computational problems with each currently in use. We suggest the Random Forest-Recurrent Feature Elimination (RF-RFE) model to increase the precision and dependability of blood cancer diagnosis. This model integrates machine learning and image processing, optimizes feature selection and refinement from high-dimensional data, and applies the XGBoost algorithm to guarantee diagnosis accuracy. Recent model analysis reveals that RF-RFE performs better than them on a wide range of metrics. The RF-RFE offered a sensible, well-rounded strategy. More research on medical diagnostics is made possible by its adaptability in multi-class classification and effectiveness in handling high-dimensional feature values. The optimized feature set and computational efficiency of the model, which may enhance leukemia detection and diagnostics, are highlighted in this study.