“…Previous attempts have showed satisfactory results in optimizing the facility layout in combination with some safety considerations using Mixed Integer Non Linear Programming (MINLP), however these findings do not guarantee the global optimum solution (Penteado & Ciric, 1996). Similarly, numerous publications for the facility layout based on toxic gas release scenarios have also not provided globally optimal solutions (Diaz-Ovalle, Jung, Ng, Lee, Vazquez-Roman, & Mannan, 2010;Vazquez-Roman, Lee, Jung, & Mannan, 2009). Thus, it is imperative to develop a new methodology to achieve global optima in the facility layout problem with fire, explosion, and toxic release scenarios.…”