Optimal Experimental Design to Estimate Insulin Response in Type 2 Diabetes
Sarah Ellinor Engell,
Henrik Bengtsson,
Karim Davari Benam
et al.
Abstract:In late-stage type 2 diabetes, automated titration algorithms provide a promising alternative to the current standard-of-care. Many published methods rely on personalized dose-response models to predict a safe and effective insulin dose. In this case study, we address the challenge of how to collect an informative data set to ensure practical identifiability of such models. We apply optimal experimental design to enhance the performance of a published titration algorithm. For a 24-hour experiment, we solve an … Show more
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