Optimal efficacy of a fungicide preparation, natamycin, in the control of the house-dust mite,Dermatophagoides pteronyssinus

Georges-Gridelet, D. De Saint

doi:10.1007/bf01213842

Cited by 12 publications

(3 citation statements)

References 4 publications

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“…In accordance with the findings of other authors [38,39] the 65-96% mite mortality rate for Tymasil reported earlier could not be confirmed [10,11,21]. Recently it was demonstrated that after treatment with twice the commercial concentration of Tymasil a long-term control of house-dust mites could be guaranteed [40].…”

Section: Discussionmentioning

confidence: 48%

Comparative efficacy of house dust mite extermination products

Schober

Kniest²,

Kort³

et al. 1992

Clin Experimental Allergy

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The acaricidal efficacy of nine marketed products, i.e. Acardust, Acarosan (foam and powder), Actelic 50, Artilin 3A (spirit and water base), liquid nitrogen, Paragerm AK, and Tymasil, and of intensive vacuum-cleaning have been compared on four different test surfaces: mattress, tufted carpet, gypsum board and rough wooden board, all covered with artificial house dust. They were inoculated with the house dust mite, Dermatophagoides pteronyssinus or the house-dust fungus Aspergillus repens for evaluation of the fungistatic claims of some products. The acaricidal activity of Tymasil did not surpass that of vacuuming; its fungistatic effect was not apparent. The other products showed complete to almost complete eradication on at least one of the substrates tested. Taking into account the results of acaricidal efficacy as well as the data on safety and practicality acquired earlier, Acarosan powder was considered first choice for carpet treatment. Acarosan and liquid nitrogen, were found to be effective in the treatment of mattress, pillow, upholstered furniture and heavy curtains. On wooden surfaces Acarosan was found to be both effective and safe, while Acardust, Actelic 50, Artilin 3A (both fungistatic as well as acaricidal), liquid nitrogen and Paragerm also passed the efficiency test.

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Section: Discussionmentioning

confidence: 48%

Comparative efficacy of house dust mite extermination products

Schober

Kniest²,

Kort³

et al. 1992

Clin Experimental Allergy

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“…This indicated that the changes were due to chance alone and not the effect of therapy. The disappointing eflect of Tymasil on the level of Der p I in the mattress dust may have been because of inadequate penetration of the whole mattress [23]; recolonization from other bedding which was not treated or because the effect of reduction of fungi on Dpt was weak. In the idea!…”

Section: Discussionmentioning

confidence: 99%

House dust mite allergen levels and an anti‐mite mattress spray (natamycin) in the treatment of childhood asthma

Reiser

Ingram

Mitchell

et al. 1990

Clin Experimental Allergy

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Natamycin, a fungicide marketed as Tymasil, is claimed to reduce house dust mite numbers and would therefore be expected to improve asthma in children with mite sensitivity. We have tested this assertion by a double-blind, placebo-controlled trial. There was no significant effect on levels of Der p I in mattress dust between active and placebo groups at the end of the spraying period. Histamine inhalation challenge PC20, clinic visit symptom scores and lung function tests reflecting either large or small airways obstruction were also unchanged. Therefore this product is not a therapeutic option for mite-allergic patients using the manufacturer's recommended dose and method of administration. Other factors influencing the Der p I levels were also investigated. Of these, only month of measurement and bedroom wall humidity showed any association.

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“…In this respect, a non-toxic fungicidal agent, natamycin, was found to inhibit the development of Dermatophagoides pteronyssinus (Trouessart) on mattress-dust substrate. Also, a reduction was noticed in the percentage of gravid females and in the average number of eggs laid per female (Saint Georges-Gridelet, 1981b, 1986bLebrun and Saint Georges-Gridelet, 1984).…”

Section: Introductionmentioning

confidence: 95%

Destruction of eggs ofDermatophagoides pteronyssinus(Acari: Pyroglyphidae) by natamycin and imidazoles in Vitro

Georges-Gridelet¹

1987

International Journal of Acarology

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The potential ovicidal activity of natamycin and four imidazoles was investigated with levilite-diatom powder and water as controls. All products tested prevented larval hatching, but not embryonic development. Irregular distribution of the products on the sprayed eggs was noted, except for natamycin. The eggs appeared surrounded in crystal formations or particle clusters. The random nature of these phenomena explains the greatly varied resuits. Its superior dispersion gives natamycin a clear advantage over the other antifungal preparations.

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Optimal efficacy of a fungicide preparation, natamycin, in the control of the house-dust mite,Dermatophagoides pteronyssinus

Cited by 12 publications

References 4 publications

Comparative efficacy of house dust mite extermination products

Comparative efficacy of house dust mite extermination products

House dust mite allergen levels and an anti‐mite mattress spray (natamycin) in the treatment of childhood asthma

Destruction of eggs ofDermatophagoides pteronyssinus(Acari: Pyroglyphidae) by natamycin and imidazoles in Vitro

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