Optimal dosing regimen of caspofungin in adolescents with allogeneic haematopoietic stem cell transplantation
Bin Du,
Wei Zhang,
Yang Wang
et al.
Abstract:Objectives
The optimal dosing regimen of caspofungin in adolescents undergoing allogeneic haematopoietic stem cell transplantation against Candida spp. is unknown. The study aimed to compare body surface area (BSA)-based and fixed dosing regimens through population pharmacokinetic (PPK) analysis and to optimize dosing regimens likely to achieve therapeutic exposures.
Methods
Opportunistic sampling was used to collect plasma c… Show more
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