Optimal Dose for Starting and Maintaining Low-Dose Aspirin

Kearon, Clive; Hirsh, Jack

doi:10.1001/archinte.1993.00410060012002

Cited by 10 publications

(3 citation statements)

References 43 publications

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“…Acetylsalicylic acid, (ASA/aspirin) has been shown to prevent pregnancy induced hypertension (PIH) in humans (48,(97)(98)(99)(100)(101)(102)(103)(104)(105)(106), and low dosages of ASA are prescribed to manage occlusive disorders like angina, myocardial infarction and to prevent re-stenosis (9,13,56,58,63,75,86,97,102,(107)(108)(109)(110)(111)(112)(113)(114)(115)(116)(117)(118)(119)(120)(121)(122)(123)(124). Aspirin has also been found to be beneficial against vascular disorders associated with diabetes (9,110,125).…”

Section: Aspirin and Its Therapeutic Usagementioning

confidence: 99%

“…Pregnancy-induced hypertension (PIH) in humans has been shown to be prevented by ASA administration (48,(97)(98)(99)(100)(101)(102)(104)(105)(106). Increasingly low aspirin dosages are being prescribed to manage and prevent various occlusive disorders such as angina, myocardial infarction and re-stenosis after angioplasty (58,63,97,101,113,115,116,120,123,131,152 ) . Aspirin reduces coronary hyperreactivity to autocoids aftert angioplasty and thus prevents re-stenosis (56,58,109,153).…”

Section: Role Of Cyclooxygenase In the Pharmacology Of Aspirinmentioning

confidence: 99%

“…Recently, ASA was found to suppress epithelial cell proliferation in rat colonic crypts (17). The beneficial effects of aspirin in vascular occlusive disease and PIH are ascribed to its blockade of the enzyme, cyclooxygenase, during the synthesis of platelet TXA 2 , a potent agonist of vascular smooth muscle contraction (37,60,63,75,108,109,112,115,116,120,122,123,139,150,152,154,155).…”

Section: Role Of Cyclooxygenase In the Pharmacology Of Aspirinmentioning

confidence: 99%

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Vascular smooth muscle endothelial regulation and effects of aspirin in hypertension

Rahmani¹

1998

Front Biosci

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Dysfunction of vascular smooth muscle (VSM) is at the center of occlusive disorders of the cardiovascular system such as hypertension, atherosclerosis, coronary artery disease and hypoxia. In addition to circulating biogenic amines and various neurotransmitters originating from the central nervous system and endocrine system, various autocoids of arachidonic acid metabolism in the blood as well as in the endothelium play an important regulatory role in the maintenance of the tone and the contractile function of VSM. A monolayer of endothelial cells lining the heart and large blood vessels is responsible for producing and releasing both endocrine and paracrine substances such as endothelins, nitric oxide, prostaglandins and prostacyclins. Aspirin, (acetylsalicylic acid/ASA) an ancient remedy against fever and pain, is emerging as an effective drug not only against occlusive disorders but also against various cancers and the AIDs virus. During pregnancy induced hypertension (PIH) and in occlusive disorders, aspirin provides relief through inhibition of cyclooxygenase, an enzyme required for the metabolism of arachidonic acid to produce prostaglandins and prostacyclins in platelets and in endothelial cells. Because of its unique molecular constitution, synergistic ability and solubility in the lipidic environment, various mechanisms of aspirin's actions are being currently investigated. In this review, the effect of aspirin on the regulation of VSM in the presence and absence of endothelium are discussed.

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