Optimal Dosage of Cyclopentolate 1% for Complete Cycloplegia: A Randomized Clinical Trial

Bagheri, Abbas; Givrad, S; Yazdani, Shahram; Mohebbi, Mohammadreza

doi:10.1177/112067210701700303

Cited by 29 publications

(35 citation statements)

References 11 publications

(12 reference statements)

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“…Bagheri et al .,[10] divided their patients into three groups and compared the cycloplegic effect of cyclopentolate 1% between one and two drops (Group 1), two and three drops (Group 2), and one and three drops (Group 3). They did not find a significant difference among these groups and concluded that a single drop of cyclopentolate was sufficient for cycloplegic refraction.…”

Section: Discussionmentioning

confidence: 99%

“…Studies on the optimal dosage of cyclopentolate are few and have been conducted with two different dosage schedules in the same patient. [910] There is no study with three different dosage schedules of cyclopentolate in the same patient. We believe that age, refractive error, iris pigmentation, and ocular deviation are the potential confounding variables with a possible effect on measured hypermetropia, as mentioned by Bagheri et al .,[10] also.…”

mentioning

confidence: 99%

“…[910] There is no study with three different dosage schedules of cyclopentolate in the same patient. We believe that age, refractive error, iris pigmentation, and ocular deviation are the potential confounding variables with a possible effect on measured hypermetropia, as mentioned by Bagheri et al .,[10] also. We also believe that using one, two, and three instillations of cyclopentolate in the same patient can eliminate these variables.…”

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confidence: 99%

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Optimal dosage of cyclopentolate 1% for cycloplegic refraction in hypermetropes with brown irides

Mohan¹,

Sharma²

2011

Indian J Ophthalmol

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To find the optimal dosage of cyclopentolate 1% for cycloplegic refraction in hypermetropes with brown irides, we investigated the difference in cycloplegic auto-refractions obtained after one, two, and three instillations in the same patient. The mean hypermetropia found after three instillations was statistically significantly more compared to that found after one instillation. There was no statistically significant difference in the mean hypermetropia between two and three instillations. There was no significant effect of gender, age, and the presence and type of horizontal deviation. These observations suggest that two drops of cyclopentolate 1% 10 min apart are sufficient for cycloplegic refraction in hypermetropes.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Optimal dosage of cyclopentolate 1% for cycloplegic refraction in hypermetropes with brown irides

Mohan¹,

Sharma²

2011

Indian J Ophthalmol

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“…One drop has been found to be effective for cycloplegic refraction whilst minimizing possible adverse effects. 2,3 The pupil was checked after 40 min and all subjects showed reasonably dilated pupils. The refractive error of the eye under cycloplegia was then measured by subjective refraction using the criterion of maximum plus lens for the best visual acuity.…”

Section: Effect Of Cycloplegiamentioning

confidence: 99%

Role of Mandelbaum-like effect in the differentiation of hyperopes and myopes using a hologram

Nguyen

Avudainayagam

2013

J. Biomed. Opt

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Abstract. Recently, we tested the vision of spectacle corrected subjects using a special hologram (http://dx.doi.org/ 10.1364/BOE.3.001173). A subject viewing through this hologram sees the images of various numbers at different distances from the eye. Each of these images subtends an angle of 50 0 at the eye. Each image corresponds to a different amount of divergence or convergence at the eye. The limit of convergence (positive blur) with which a subject can recognize the numbers was measured. Hyperopes could recognize numbers with 0.9 D more of positive blur in comparison with myopes. This difference was not obtained with a standard test chart under white light illumination using positive lenses to provide the blur. The observed difference with the hologram is then attributed to the multivergence nature of the target in the hologram and/or the monochromaticity of the illumination used. Using a hologram of a logMAR chart at a single distance of infinity we have now found that the observed difference is induced by the multivergence target and is due to an effect that is similar to the Mandelbaum effect. We present the details of this experiment and compare the results obtained with our earlier experiment. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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“…1 Importantly, most other studies that evaluated the safety and efficacy of cycloplegic agents used various regimens, such as one or two drops of cyclopentolate 1,4,6,7,9,10 or a combination of cyclopentolate with tropicamide. 1,4,11 The results of our study might not be applicable for the use of these other regimens.…”

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confidence: 99%

Time of maximum cycloplegia after instillation of cyclopentolate 1% in children with brown irises

Pukrushpan¹,

Laojaroenwanit²,

Layanun³

et al. 2016

Journal of American Association for Pediatric Ophthalmology and

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Purpose: We aimed to 1) determine the time of maximum cycloplegia after instillation of cyclopentolate 1% in children with brown irises, 2) evaluate the correlation between the pupillary reaction and time of maximum cycloplegia, and 3) identify any side effects of the medication. Patients and methods: This was a prospective analytical study involving children aged 5 to 14 years who were attending refraction clinic. Cyclopentolate 1% was instilled three times at 10-minute intervals. The spherical equivalent, pupillary reaction, and pupillary diameter were recorded before the first drop and nine times after the last drop at 10-minute intervals. Side effects were assessed. Time of maximum cycloplegia was determined from the time point at which the 95% confidence interval of the differences between the mean spherical equivalent at each point and its final value at 110 minutes was reached and remained within the equivalence limit (±0.25 D). Results: Sixty children were enrolled in this study. Their mean age was 9.8 years (range: 5-14 years). Time of maximum cycloplegia was reached at 30 minutes after the first instillation of cyclopentolate. A poor correlation was observed between the pupillary reaction and the time of maximum cycloplegia (r=-0.07). The mean pupillary diameter at 30 minutes was 3.7±1.3 mm, and further dilation occurred thereafter. No side effects were observed. Conclusion: In most children, maximum cycloplegia was reached 30 minutes after the first instillation of cyclopentolate. The absence of a pupillary reaction should not be used as an indicator of maximum cycloplegia.

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Optimal Dosage of Cyclopentolate 1% for Complete Cycloplegia: A Randomized Clinical Trial

Abstract: A single drop of cyclopentolate 1% suffices for cycloplegic refraction. There were less frequent side effects using one drop of cyclopentolate, compared to two or three drops.

Cited by 29 publications

References 11 publications

Optimal dosage of cyclopentolate 1% for cycloplegic refraction in hypermetropes with brown irides

Optimal dosage of cyclopentolate 1% for cycloplegic refraction in hypermetropes with brown irides

Role of Mandelbaum-like effect in the differentiation of hyperopes and myopes using a hologram

Time of maximum cycloplegia after instillation of cyclopentolate 1% in children with brown irises

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