Optimal Diagnostic Algorithm for Colorectal Cancer Complicated by Acute Bowel Obstruction

Тотиков, З. В.; Тотиков, В. З.; Remizov, O. V.; Гадаев, Ш. Ш.; Магомадов, Э. А.; Ардасенов, Т. Б.; Тарамов, У. У.; Abdurzakov, M.A.

doi:10.33878/2073-7556-2020-19-3-72-79

Cited by 4 publications

(1 citation statement)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Currently, the restoration of colonic continuity during colostomy is one of the urgent tasks of abdominal surgery, the sole purpose of which is to improve the quality of life of patients (Lyhman, 2015;Totikov and Totikov, 2014). This intervention is a technically complex operation associated with adhesive disease of the abdominal cavity.…”

Section: Research Articlementioning

confidence: 99%

The Effect of 5-Fluorouracil on the Adhesion Process in Patients Operated on for Colorectal Cancer

Zhakipbekov

Osombaev

Irimbetov

2022

Asian Pac J Cancer Prev

View full text Add to dashboard Cite

Objective: The aim of this study was to improve the direct results of reconstructive surgery in patients operated on for complicated forms of colorectal cancer, by using 5-fluorouracil in the postoperative period. Methods: The study involved 126 patients (they were divided into 2 groups) with colorectal cancer, who underwent reconstructive surgery. They underwent a standard clinical examination and a mandatory examination program. Results: The use of 5-fluorouracil in adjuvant treatment in patients with colorectal cancer significantly reduces the number of subjective clinical manifestations (positional tests) in the main group – 17%, and in the control group – 54.3%, as well as objective clinical manifestations (instrumental research methods) in Group I – 13%, and Group II – 89.5%, respectively. The study shows that in re-operated patients with colorectal cancer who received 5-fluorouracil, abdominal adhesions are characterized by a low content of collagen and fibroblasts, low vascularization and a high content of polymerized fibrin strands. It was also found that re-operated patients with colorectal cancer who did not receive 5-fluorouracil, abdominal adhesions are characterized by a high collagen content, a large number of fibroblasts, and severe angiogenesis. Conclusion: It was found that the prolonged administration of 5-fluorouracil statistically significantly reduces the risk of adhesions, thereby showing the effectiveness of preventing adhesive disease of the abdominal organs. It was shown that the prolonged administration of 5-fluorouracil significantly reduces the number of subjective and objective signs of adhesive disease of the abdominal organs, as well as significantly decreases intraoperative and postoperative complications, the duration of the operation, and the amount of blood loss. In the postoperative period, it reduces the length of hospital stay and improves the quality of life of patients.

show abstract

Section: Research Articlementioning

confidence: 99%

The Effect of 5-Fluorouracil on the Adhesion Process in Patients Operated on for Colorectal Cancer

Zhakipbekov

Osombaev

Irimbetov

2022

Asian Pac J Cancer Prev

View full text Add to dashboard Cite

show abstract

Improvement of preoperative infusion therapy in patients with acute large bowel obstruction

Неймарк¹,

Zhukov²

2022

Anaes. i reanim.

View full text Add to dashboard Cite

Comparative analysis of clinical and morphological data of patients of different age groups who underwent emergency surgical interventions for complicated colon cancer

Shchaeva

2023

Onkol. koloproktol.

View full text Add to dashboard Cite

The aim of the study was to conduct a comparative analysis of clinical and morphological data of patients of different age groups after emergency resection interventions for complicated colon cancer. Materials and methods. The retrospective cohort study included 227 patients who underwent emergency operations for complicated colon cancer during the period from September 2016 to December 2022. Two groups of patients were selected: group 1 – under 60 years old, group 2–60 years old and older. In the 2nd group, 2 subgroups were selected: patients aged between 60 to 74 years and patients between 75 years and older. The primary point of the study was assessment of postoperative complications according to the Clavien–Dindo classification within 30 days after surgery. The secondary point was study of oncological adequacy of the operation. Results. The study included 128 (56.4 %) women and 99 (43.6 %) men. The median age was 66 years. Forty seven (20.7 %) patients were included in the group of persons younger than 60 years; 180 (79.3 %) patients were included in the group 60 years and older. There were no differences between the groups by gender and tumor localization. Tumor perforation was more often recorded in group 2 (23.3 % and 4.3 %, p = 0.017). High comorbidity was also more often observed in group 2 (46.8 % and 100 %, p = 0.023). In group 2, the physical status mostly corresponded to ASA grade 3 and 4 (p = 0.031). The difference between the groups by T-status was revealed: in group 1, there were more cases of T2-T3 (76.6 % vs. 46.7 %), and in group 2 – of T4 (53.3 % vs. 23.4 %), p = 0.034. Most patients in group 1 had the pN2 status (68.1 %), however, the pN1 status prevailed in the 2nd group (70 %). There were more oncologically inadequate operations in group 2: 54 (30 %) compared with group 1–2 (4.3 %) (p = 0.004). The main factors influencing the radicality of the performed operation were the type of urgent complication – tumor perforation (odds ratio (OR) 1.81, 95 % CI 1.43–3.96, p = 0.002); type of surgery (the Hartmann type surgery) (OR 1.62, 95 % CI 1.22–3.83, p <0.001); age OR 0.76, 95 % CI 0.54–1.33, p = 0.004); comorbidity (OR 0.61, 95 % CI 0.43–1.28, p = 0.02); physical status of patients according to ASA classification grade 3–4 at admission (OR 0.52, 95 % CI 0.30–1.49, p = 0.002); tumor localization (OR 0.43, 95 % CI 0.28–1.15, p = 0.011). Conclusion. Emergency operations for complicated colon cancer are characterized by a high risk of serious postoperative complications, especially in elderly and senile patients. In patients younger than 60 years of age, the malignant tumors are often characterized by more aggressive course with damage to regional lymph nodes (N2 status).

show abstract

Optimal Diagnostic Algorithm for Colorectal Cancer Complicated by Acute Bowel Obstruction

Cited by 4 publications

References 5 publications

The Effect of 5-Fluorouracil on the Adhesion Process in Patients Operated on for Colorectal Cancer

The Effect of 5-Fluorouracil on the Adhesion Process in Patients Operated on for Colorectal Cancer

Improvement of preoperative infusion therapy in patients with acute large bowel obstruction

Comparative analysis of clinical and morphological data of patients of different age groups who underwent emergency surgical interventions for complicated colon cancer

Contact Info

Product

Resources

About