“…Minimization of entropy generation as a design tool to determine best device geometry and operation, especially for heat exchangers, has been established for macro-scale configurations (see Bejan 1996Bejan , 2002Sahin 1998Sahin , 2000Mahmud & Fraser 2003;Mansour et al 2006;Khan et al 2007;Ko & Wu 2009; among others). However, fluid flow in microchannels exhibits dominant features often non-existing or less influential in macrochannels, e.g., wall-slip velocities for some gases, entrance effects because of the short conduit length, significant surface roughness in relation to microchannel height (or hydraulic diameter), etc.…”