Abbreviations e Eccentricity between shaft and bearing, m C Radial clearance, m R Radius of the shaft, m h Film thickness, m ω Angular velocity, rad/sec W Load carrying capacity, N O' Bearing centre O Shaft centre ρ Fluid density, kg/m 3 ρ l Liquid density, kg/m 3 ρ v Vapor density, (kg/m 3) v Fluid velocity P Static pressure, Pa τ Stress tensor F External body force, N t Time ε Eccentricity ratio σ Liquid surface tension coefficient v Fluid velocity vector C e , C c Mass transfer source terms connected to the growth and collapse of the vapor bubbles, respectively F cond Condensation coefficient F evap Evaporation coefficient p v Saturation pressure of the fluid [M s ] Structural mass matrix [M f ] Fluid mass matrix [F s ] Structural force matrix [F f ] Fluid force matrix [R] Coupling matrix Δh Relative rigid displacement of the two bearing surfaces δ Total elastic deformation of the shaft and bearing system Abstract This work deals with a study of a three-dimensional CFD analysis and multi-phase flow phenomena for hydrodynamic journal bearing with integrated cavitation. The simulations are carried out considering the realistic bearing deformations by two-way fluid-structure interactions (FSI) along with cavitation using ANSYS ® Workbench software. The design optimization module is used to generate the optimized solution of the attitude angle and eccentricity for the combination of operating speed and load. Bearings with and without cavitation are investigated. A drop in maximum pressure value is observed when cavitation is considered in the bearing. The rise in oil vapor distribution is noted with an increase in shaft speed which lowers the magnitude of the pressure build up in the bearing. The bearing deformations are analyzed numerically and found increasing with an increase in shaft speed. The experimental data obtained for pressure distribution showed good agreement with numerical data along with a considerable reduction in computation time.