Optimal design and experimental validation of a simulated moving bed chromatography for continuous recovery of formic acid in a model mixture of three organic acids from Actinobacillus bacteria fermentation

Park, Chanhun; Nam, Hee Geun; Lee, Ki Bong; Mun, Sungyong

doi:10.1016/j.chroma.2014.09.005

Cited by 12 publications

(7 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other technologies such as distillation [228,238], crystallization [239][240][241], and chromatography [241] are often used as a further purification step to refine the final acid [228]. Nowadays, precipitation is the most employed recovery method at industrial scale, thus indicating its economic advantage with respect to the other strategies [228,232].…”

Section: Downstream Strategiesmentioning

confidence: 99%

Fungal‐Based Biorefinery: From Renewable Resources to Organic Acids

Varriale

Ulber

2023

ChemBioEng Reviews

View full text Add to dashboard Cite

Biorefineries are facilities in which lignocellulosic biomasses are converted in a wide range of bioproducts facilitating the transition from the use of petrochemical resources to renewable ones. Organic acids are considered very attractive for their utilization in different industrial areas as building blocks or as final bioproducts leading to a considerable market growth. They are metabolites which are naturally produced by microbials. The production of these molecules by filamentous fungi are attracting more attention due to their ability to hydrolyze lignocellulosic biomasses and to contextually produce different organic acids. Contrarily to a lot of other microorganisms, fungi have the ability to ferment pentoses, broadening the substrate utilization. The integrated use of lignocellulosic biomasses as material input and fungi as biocatalyst can contribute to make biorefineries more successful. This review gives an overview about the lignocellulosic biomass structure and hydrolysis, fungal morphology, and how they are connected. Further, it describes some relevant organic acids with regard to their processes, biocatalysts, industrial applications, and market considerations.

show abstract

Section: Downstream Strategiesmentioning

confidence: 99%

Fungal‐Based Biorefinery: From Renewable Resources to Organic Acids

Varriale

Ulber

2023

ChemBioEng Reviews

View full text Add to dashboard Cite

show abstract

“…The importance of biological production of organic compounds is growing with increased demands and needs for adapted downstream processes to increase production rates. Various methods such as precipitation, − chromatography, , ion-exchange, − adsorption, − distillation, , crystallization, , membrane separation, − and liquid extraction − have been reported for the separation of high valued organic acids from aqueous solutions (waste streams/fermentation broths). These separation and recovery methods, have some advantages and disadvantages in their operations.…”

Section: Recovery Of Organic Acids From Aqueous Solution/fermentation...mentioning

confidence: 99%

Reactive Extraction as an Intensifying Approach for the Recovery of Organic Acids from Aqueous Solution: A Comprehensive Review on Experimental and Theoretical Studies

et al. 2021

View full text Add to dashboard Cite

Organic acids are important targeted chemicals worldwide due to their variety of functionalities in various fields. Organic acids can be produced through chemical processes of fossil raw materials as well as by the microbial fermentation of natural occurring biomass. Because of growing environmental concern, the production pathways are shifting toward biobased green technologies. The primary challenge in the biological synthesis of organic acids is the downstream recovery of the main products from the fermentation broth/aqueous stream. Among the various techniques for the downstream processing, reactive (liquid) extraction is deemed as a great opportunity for this purpose. It is an energy-saving process with flexibility in production scale and a high degree of separation and selectivity. In this review, starting with highlighting the bioproduction and various alternatives available for the recovery of organic acids from aqueous solution, the reactive extraction, an intensified approach is described in detail. The influence of reactive extraction parameters, insights of equilibrium and kinetic mechanisms, and thermodynamic aspects are discussed and analyzed. Different theoretical models for process optimization, determination of equilibrium, kinetic, and thermodynamic parameters, and quantification of solvents' effect are also explained in detail. This paper also highlights recent experimental and theoretical studies for the recovery of different organic acids using amine, phosphorus, and ionic liquid based extractants from fermentation broth/ industrial waste streams. In addition, industrial development on the recovery of organic acids using the reactive extraction approach is also described.

show abstract

“…486 Indicative case studies in waste valorisation. The literature provides a long list of potential SMB applications, such as purifications of organic acids, 494,[500][501][502][503] amino acids, [504][505][506] and pharmaceutics, 507 which include enzymes, 485 monoclonal antibodies, 508 paclitaxel (a chemotherapeutic drug), 483 ascomycin derivative (an anti-inflammatory drug), 509 biosynthetic human insulin, 510,511 and many others.…”

Section: Basic Smb Principlesmentioning

confidence: 99%