Optimal CXCR5 Expression during Tfh Maturation Involves the Bhlhe40-Pou2af1 Axis
Xiaoliang Zhu,
Xi Chen,
Yaqiang Cao
et al.
Abstract:The pair of transcription factors Bcl6-Blimp1 is well-known for follicular T helper (Tfh) cell fate determination, however, the mechanism(s) for Bcl6-independent regulation of CXCR5 during Tfh migration into germinal center (GC) is still unclear. In this study, we uncovered another pair of transcription factors, Bhlhe40-Pou2af1, that regulates CXCR5 expression. Pou2af1 was specifically expressed in Tfh cells whereas Bhlhe40 expression was found high in non-Tfh cells. Pou2af1 promoted Tfh formation and migratio… Show more
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