Optimal cutoff value of high-density lipoprotein cholesterol for predicting coronary artery disease in Taiwanese population

Huang, Yann-Chang; Ho, Chien-Chang; Lin, Ping-Ting; Lee, Bor‐Jen; Lai, Cheng-Hsiu; Liaw, Yung‐Po

doi:10.1016/j.nutres.2009.11.003

Cited by 8 publications

(9 citation statements)

References 31 publications

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“…The established cut‐off values; that is, those for EPA/AA (≥0.5), GSM (<32) and IMT (≥1.0 mm), were obtained from previous reports. Furthermore, receiver operating characteristic (ROC) analysis was carried out to determine the optimal cut‐off points for PA and PS to acquire the R 2 score of the logistic regression analysis, with routine adjustment for other risk confounders. Thus, we estimated the optimal cut‐off points associated with CVD events in our patients as follows; PA (≥20,000 V) and PS (≥5.0 mm).…”

Section: Methodsmentioning

confidence: 99%

Ultrasound analysis of gray‐scale median value of carotid plaques is a useful reference index for cerebro‐cardiovascular events in patients with type 2 diabetes

Ariyoshi

Okuya

Kunitsugu

et al. 2014

J of Diabetes Invest

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Aims/IntroductionMeasurements of plaque echogenicity, the gray-scale median (GSM), were shown to correlate inversely with risk factors for cerebro-cardiovascular disease (CVD). The eicosapentaenoic acid (EPA)/arachidonic acid (AA) ratio is a potential predictor of CVD risk. In the present study, we assessed the usefulness of carotid plaque GSM values and EPA/AA ratios in atherosclerotic diabetics.Materials and MethodsA total of 84 type 2 diabetics with carotid artery plaques were enrolled. On admission, platelet aggregation and lipid profiles, including EPA and AA, were examined. Using ultrasound, mean intima media thickness and plaque score were measured in carotid arteries. Plaque echogenicity was evaluated using computer-assisted quantification of GSM. The patients were then further observed for approximately 3 years.ResultsGray-scale median was found to be a good marker of CVD events. On multivariate logistic regression analysis, GSM <32 and plaque score ≥5 were significantly associated with past history and onset of CVD during the follow-up period, the odds ratios being 7.730 (P = 0.014) and 4.601 (P = 0.046), respectively. EPA/AA showed a significant correlation with GSM (P = 0.012) and high-density lipoprotein cholesterol (P = 0.039), and an inverse correlation with platelet aggregation (P = 0.046) and triglyceride (P = 0.020). Although most patients with CVD had both low GSM and low EPA/AA values, an association of EPA/AA with CVD events could not be statistically confirmed.ConclusionsThe present results suggest the GSM value to be useful as a reference index for CVD events in high-risk atherosclerotic diabetics. Associations of the EPA/AA ratio with known CVD risk factors warrant a larger and more extensive study to show the usefulness of this parameter.

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Section: Methodsmentioning

confidence: 99%

Ultrasound analysis of gray‐scale median value of carotid plaques is a useful reference index for cerebro‐cardiovascular events in patients with type 2 diabetes

Ariyoshi

Okuya

Kunitsugu

et al. 2014

J of Diabetes Invest

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“…According to the ROC analyses, the AUC for the virusbased ELISA was similar to those of the SP2, SP3, and SP6 ELISAs, but greater than those of the SP1, SP5, and SP7 ELISAs. The SP4 ELISA result revealed that SP4 could be considered as a target serological testing protein, as the AUC was close to 0.9 (indicating that the ELISA could meet the required diagnostic standards) (Huang et al, 2010;Sucheeva et al, 2013).…”

Section: Discussionmentioning

confidence: 95%

Evaluation of purified recombinant spike fragments for assessment of the presence of serum neutralizing antibodies against a variant strain of porcine epidemic diarrhea virus

et al. 2017

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Since 2010, variant strains of porcine epidemic diarrhea virus (PEDV) have caused disasters in the pork industry. The spike (S) protein, as the major immunity-eliciting antigen, has previously been used for serological testing and has been found to correlate significantly with the results of the serum neutralization (SN) test. However, further evaluation of this method is needed as new epidemic strains of PEDV emerge. Hence, the main objective of this study was to assess sow sera and determine the correlation between enzyme-linked immunosorbent assay (ELISA) results (involving a newly isolated GDS01 virus-based ELISA and ELISAs based on seven recombinant fragments comprising overlapping S1 and partial S2 sequences) and SN titers. Furthermore, we determined the reliability of the ELISAs based on receiver operating characteristics (ROC) curve analyses. For the most promising ELISA, i.e., the SP4 ELISA, the correlation coefficient (r) and the area under curve (AUC) were determined to be 0.6113 and 0.8538, respectively. In addition, we analyzed the homology of the SP4 sequences obtained from different strains (including vaccine strains) and found that various strains showed a high degree of homology in this region. Thus, we conclude that SP4 is a promising serological testing protein for use in the field.

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“…Our previous study suggested that, as opposed to a decrease in LDL-C levels, an increase in HDL-C could better prevent the occurrence of CAD (Huang et al, 2010). Therefore, appropriate exercise can be included in the guidelines for the prevention of cardiovascular diseases.…”

Section: Discussionmentioning

confidence: 99%

“…Although statin therapy reduces the incidence of coronary artery disease (CAD) by approximately 30%, substantial residual cardiovascular risk remains, even with very aggressive reductions in blood concentrations of low-density lipoprotein cholesterol (LDL-C; Cannon et al, 2004;Downs et al, 1998). Our previous study showed that subjects with lower levels of high-density lipoprotein cholesterol (HDL-C) have a much higher risk of CAD than those with higher levels of LDL-C (Huang et al, 2010). Observational studies have shown that each 1-mg/ dl decrease in plasma HDL-C concentration is associated with a 2-3% increased risk of CAD (Chapman, Assmann, Fruchart, Shepherd, & Sirtori, 2004;Tulenko & Sumner, 2002).…”

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confidence: 99%

A Simple Method for Increasing Levels of High-Density Lipoprotein Cholesterol: A Pilot Study of Combination Aerobic- and Resistance-Exercise Training

Tseng¹,

Ho²,

Chen³

et al. 2013

International Journal of Sport Nutrition and Exercise Metabolism

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Evidence suggests that physical activity has a beneficial effect of elevated high-density lipoprotein cholesterol (HDL-C) on reducing coronary artery risk. However, previous studies show contrasting results for this association between different types of exercise training (i.e., aerobic, resistance, or combined aerobic and resistance training). The aim of this study was to determine which type of exercise training is more effective in increasing HDL-C levels. Forty obese men, age 18-29 yr, were randomized into 4 groups: an aerobic-training group (n = 10), a resistance-training group (n = 10), a combined-exercise-training group (n = 10), and a control group (n = 10). After a 12-wk exercise program, anthropometrics, blood biochemical variables, and physical-fitness components were compared with the data obtained at the baseline. Multiple-regression analysis was used to evaluate the association between different types of exercise training and changes in HDL-C while adjusting for potential confounders. The results showed that with the control group as the comparator, the effects of combined-exercise training (β = 4.17, p < .0001), aerobic training (β = 3.65, p < .0001), and resistance training (β = 2.10, p = .0001) were positively associated with increase in HDL-C after adjusting for potential confounders. Our findings suggested that a short-term exercise program can play an important role in increasing HDL-C levels; either aerobic or resistance training alone significantly increases the HDL-C levels, but the improvements are greatest with combined aerobic and resistance training.

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Optimal cutoff value of high-density lipoprotein cholesterol for predicting coronary artery disease in Taiwanese population

Cited by 8 publications

References 31 publications

Ultrasound analysis of gray‐scale median value of carotid plaques is a useful reference index for cerebro‐cardiovascular events in patients with type 2 diabetes

Ultrasound analysis of gray‐scale median value of carotid plaques is a useful reference index for cerebro‐cardiovascular events in patients with type 2 diabetes

Evaluation of purified recombinant spike fragments for assessment of the presence of serum neutralizing antibodies against a variant strain of porcine epidemic diarrhea virus

A Simple Method for Increasing Levels of High-Density Lipoprotein Cholesterol: A Pilot Study of Combination Aerobic- and Resistance-Exercise Training

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