Optimal cutoff points for HOMA-IR and QUICKI in the diagnosis of metabolic syndrome and non-alcoholic fatty liver disease: A population based study

Motamed, Nima; Miresmail, Seyed Javad Haji; Rabiee, Behnam; Keyvani, Hossein; Farahani, Behzad; Maadi, Mansooreh; Zamani, Farhad

doi:10.1016/j.jdiacomp.2015.11.019

Cited by 56 publications

(38 citation statements)

References 25 publications

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“…In a recent population-based study in Iran, the best cut-off for NAFLD diagnosed by ultrasound was 2.0 in women and 1.8 in men [32]. Even though these results in different ethnic groups seem consistent, it will be important to perform studies in ethnic groups other than Finns.…”

Section: H-mrs a Homa-irmentioning

confidence: 94%

Use of HOMA-IR to diagnose non-alcoholic fatty liver disease: a population-based and inter-laboratory study

et al. 2017

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Section: H-mrs a Homa-irmentioning

confidence: 94%

Use of HOMA-IR to diagnose non-alcoholic fatty liver disease: a population-based and inter-laboratory study

et al. 2017

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“…Commercially available ELISA (enzyme‐linked immunosorbent assay) kit was used to assess serum levels of insulin (Monobind, USA; inter‐ and intra‐assay CVs were 2.9% and 5.8%, respectively). Homeostatic model assessment of insulin resistance {HOMA‐IR= [fasting insulin (μIU/mL)×fasting glucose (mg/dL)/405]}, quantitative insulin sensitivity check index {QUICKI= 1/[Log (fasting insulin) (μIU/mL)] + [Log (fasting glucose) (mg/dL)]}, and homeostasis model assessment of beta‐cell function {HOMA‐ β= [360×fasting insulin (μIU/mL)]/[fasting glucose (mg/dL) − 63]} were measured by specific equation (Hong, Chung, & Cho, ; Motamed et al, ).…”

Section: Methodsmentioning

confidence: 99%

The Effect of Resveratrol Supplementation on Cardio‐Metabolic Risk Factors in Patients with Type 2 Diabetes: A Randomized, Double‐Blind Controlled Trial

Abdollahi

Salehi‐Abargouei

Toupchian

et al. 2019

Phytotherapy Research

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The aim of the present randomized controlled trial was to evaluate the effect of a micronized resveratrol supplement on glycemic status, lipid profile, and body composition in patients with type 2 diabetes mellitus (T2DM). A total of 71 overweight patients with T2DM (body mass index ranged 25–30) were randomly assigned to receive 1000 mg/day trans‐resveratrol or placebo (methyl cellulose) for 8 weeks. Anthropometric indices and biochemical indices including lipid and glycemic profile were measured before and after the intervention. In adjusted model (age, sex, and baseline body mass index), resveratrol decreased fasting blood sugar (−7.97±13.6 mg/dL, p=0.05) and increased high density lipoprotein (3.62±8.75 mg/dL, p=0.01) levels compared with placebo. Moreover, the mean difference in insulin levels reached significance (−0.97±1.91, μIU/mL, p= 0.02). However, no significant differences were observed for anthropometric measures. It was found that 8‐week resveratrol supplementation produced useful effects on some cardio‐metabolic parameters in patients with T2DM. More studies are needed to confirm these findings.

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“…21,22 HOMA-IR was calculated by multiplying glucose (mg/dL) by insulin (µU/mL) and dividing by 405. 23 The cutoff value of 2.56 was used to diagnose for IR, as previously reported in Korean adults.…”

Section: Definition Of Irmentioning

confidence: 99%

Insulin Resistance Is a Risk Factor for Silent Lacunar Infarction

Lee

Shin

Yun

et al. 2016

Stroke

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Background and Purpose— This study aims to investigate the association between insulin resistance (IR) and silent lacunar infarction (SLI) in healthy adults. Methods— We recruited 2326 healthy Korean adults who took health checkups, including a brain magnetic resonance imaging. SLI was defined as an infarction measuring 0.3 to 1.5 cm in diameter that was localized in the territory of perforating branches of cerebral arteries, as seen in the brain magnetic resonance imaging. The homeostasis model assessment–estimated insulin resistance index was used for IR estimation, and the cutoff value for its diagnosis for Koreans was 2.56. Results— The mean age of the study population was 56.2 years (range, 40–79 years), and 1279 subjects (55.0%) were male. The prevalence of SLI and IR was 8.1% and 18.1%, respectively. In multivariate logistic analysis, after adjusting for traditional SLI-associated risk factors, IR was positively associated with the prevalence of SLI (adjusted odds ratio, 1.69; 95% confidence interval, 1.16–2.46). The proportion of subjects with multiple SLI lesions (≥2) was also higher in the IR (+) group than that in the IR (−) group (4.3% versus 1.7%; P <0.001). In ordered logistic regression, IR was positively associated with an increase in SLI severity (adjusted odds ratio, 1.76; 95% confidence interval, 1.21–2.56). Conclusions— IR is an independent risk factor of SLI presence and its severity in Koreans. Whether improvement of IR might prevent SLI occurrence needs to be addressed by clinical trials.

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Optimal cutoff points for HOMA-IR and QUICKI in the diagnosis of metabolic syndrome and non-alcoholic fatty liver disease: A population based study

Cited by 56 publications

References 25 publications

Use of HOMA-IR to diagnose non-alcoholic fatty liver disease: a population-based and inter-laboratory study

Use of HOMA-IR to diagnose non-alcoholic fatty liver disease: a population-based and inter-laboratory study

The Effect of Resveratrol Supplementation on Cardio‐Metabolic Risk Factors in Patients with Type 2 Diabetes: A Randomized, Double‐Blind Controlled Trial

Insulin Resistance Is a Risk Factor for Silent Lacunar Infarction

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