Optimal crown–rump length for measuring the nuchal translucency

Wax, Joseph R.; Pinette, Michael G.; Cartin, Angelina; Blackstone, Jacquelyn

doi:10.1002/jcu.20382

Cited by 4 publications

(2 citation statements)

References 11 publications

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“…Several factors are known to improve NT measurement success, including use of transvaginal sonography, repeat measurement attempts, and a gestational age of 11–12 weeks. 10, 11 In a previous report of an 87% NT success rate, transvaginal ultrasound was employed in 7.8% of patients, notably less often than the current study's report of 18.2%. 11 Repeat measurements attempts were made in 25.6% of the current study's subjects, similar to the 25.0% repeat attempt rate in the earlier report.…”

Section: Discussioncontrasting

confidence: 53%

“…10, 11 In a previous report of an 87% NT success rate, transvaginal ultrasound was employed in 7.8% of patients, notably less often than the current study's report of 18.2%. 11 Repeat measurements attempts were made in 25.6% of the current study's subjects, similar to the 25.0% repeat attempt rate in the earlier report. 1 However, 45% of women in the current investigation were at >12 weeks' gestation at the time of the NT examination.…”

Section: Discussioncontrasting

confidence: 53%

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Stepwise sequential aneuploidy screening in clinical practice

Wax

Cartin

Smith

et al. 2011

J of Clinical Ultrasound

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Section: Discussioncontrasting

confidence: 53%

Section: Discussioncontrasting

confidence: 53%

Stepwise sequential aneuploidy screening in clinical practice

Wax

Cartin

Smith

et al. 2011

J of Clinical Ultrasound

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First trimester serum tests for Down's syndrome screening

Alldred

Takwoingi

Guo

et al. 2015

Cochrane Database of Systematic Reviews

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Tests involving two markers in combination with maternal age, specifically PAPP-A, free βhCG and maternal age are significantly better than those involving single markers with and without age. They detect seven out of 10 Down's affected pregnancies for a fixed 5% FPR. The addition of further markers (triple tests) has not been shown to be statistically superior; the studies included are small with limited power to detect a difference.The screening blood tests themselves have no adverse effects for the woman, over and above the risks of a routine blood test. However some women who have a 'high risk' screening test result, and are given amniocentesis or chorionic villus sampling (CVS) have a risk of miscarrying a baby unaffected by Down's. Parents will need to weigh up this risk when deciding whether or not to have an amniocentesis or CVS following a 'high risk' screening test result.

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First and second trimester serum tests with and without first trimester ultrasound tests for Down's syndrome screening

Alldred

Takwoingi

Guo

et al. 2017

Cochrane Database of Systematic Reviews

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Tests involving first trimester ultrasound with first and second trimester serum markers in combination with maternal age are significantly better than those without ultrasound, or those evaluating first trimester ultrasound in combination with second trimester serum markers, without first trimester serum markers. We cannot make recommendations about a specific strategy on the basis of the small number of studies available.

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Optimal crown–rump length for measuring the nuchal translucency

Abstract: NT measurements are most successful at CRL 45-66 mm corresponding to sonographically determined gestational ages of 11-0/7 to 12-6/7 weeks.

Cited by 4 publications

References 11 publications

Stepwise sequential aneuploidy screening in clinical practice

Stepwise sequential aneuploidy screening in clinical practice

First trimester serum tests for Down's syndrome screening

First and second trimester serum tests with and without first trimester ultrasound tests for Down's syndrome screening

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