Optimal control solutions for crystal shape manipulation

Bajçinca, Naim; de, Víctor; Borchert, Christian; Raisch, Joerg; Sundmacher, Kai

doi:10.1016/s1570-7946(10)28126-9

Cited by 13 publications

(22 citation statements)

References 7 publications

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“… 9 , 69 Only recently, attempts have been made to influence not only the size, but also the shape of crystals via this approach. 8 , 9 , 56 , 70 , 71 Still, most studies on crystal shape tuning are of theoretical nature. Limitations of analytical tools to quantify the multidimensional shape of microcrystals have been recognized as a major bottleneck in controlling the crystal shape.…”

Section: Crystal Shape Tuningmentioning

confidence: 99%

Crystal Engineering in Continuous Plug-Flow Crystallizers

Besenhard

Neugebauer

Scheibelhofer

et al. 2017

Crystal Growth & Design

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Size, shape, and polymorphic form are the critical attributes of crystalline particles and represent the major focus of today’s crystallization process design. This work demonstrates how crystal properties can be tuned efficiently in solution via a tubular crystallizer that facilitates rapid temperature cycling. Controlled crystal growth, dissolution, and secondary nucleation allow a precise control of the crystal size and shape distribution, as well as polymorphic composition. Tubular crystallizers utilizing segmented flow such as the one presented in our work can provide plug flow characteristics, fast heating and cooling, allowing for rapid changes of the supersaturation. This makes them superior for crystal engineering over common crystallizers. Characterization of particle transport, however, revealed that careful selection of process parameters, such as tubing diameter, flow rates, solvents, etc., is crucial to achieve the full benefits of such reactors.

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Section: Crystal Shape Tuningmentioning

confidence: 99%

Crystal Engineering in Continuous Plug-Flow Crystallizers

Besenhard

Neugebauer

Scheibelhofer

et al. 2017

Crystal Growth & Design

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“…Optimal control algorithms and strategies for crystal shape manipulation were explored to obtain minimum time trajectories with the temperature as the control input [100]. Optimal scenarios with subsequent growth and dissolution phases were investigated and it was found that minimum-time scenarios were composed of constant supersaturation trajectory sections.…”

Section: Multi-dimensional and Morphological Population Balance Modelsmentioning

confidence: 99%

Measurement, modelling, and closed-loop control of crystal shape distribution: Literature review and future perspectives

2016

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Crystal morphology is known to be of great importance to the end-use properties of the crystal product and affect the down-stream processing such as in filtration and drying, but was previously regarded as too challenging to achieve automatic closed-loop control. As a consequence, previous work has focused on control the crystal size distribution (CSD) where the size of a crystal is often defined as the diameter of a sphere that has the same volume of the crystal. This paper reviews very promising new advances made in recent years in morphological population balance models for modelling and simulation of crystal shape distribution (CShD), measurement and estimation of crystal facet growth kinetics, as well as in 2D and 3D imaging for on-line characterisation of crystal morphology and CShD. A framework is presented integrating various components in order to achieve the ultimate objective of model-based closed-loop control of CShD. The knowledge gaps and challenges that require further research are also identified.

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“…Shape control is also possible by manipulating the operating parameters during crystallization. The control of supersaturation is the most common way to manipulate crystal shape [6][7][8] , although it provides a very narrow window for shape manipulation 9 .…”

Section: Introductionmentioning

confidence: 99%