Optimal Constrained Field Focusing for Hyperthermia Cancer Therapy: A Feasibility Assessment on Realistic Phantoms

Iero, Domenica A. M.; Isernia, Tommaso; Morabito, Andrea Francesco; Catapano, Ilaria; Crocco, Lorenzo

doi:10.2528/pier10011207

Cited by 53 publications

(48 citation statements)

References 30 publications

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“…These frequencies were proposed because it was necessary to find a compromise between aperture dimensions and penetration depth, which is limited by frequency. The main goal is to obtain a non-invasive focused applicator able to locally treat tumors at depths greater than 2 cm [18,19].…”

Section: Rectangular Waveguide Design Theory and Aperture Reductionmentioning

confidence: 99%

Fem Modeling for Performance Evaluation of an Electromagnetic Oncology Deep Hyperthermia Applicator When Using Monopole, Inverted T, and Plate Antennas

Trujillo-Romero¹,

Salas²,

Vera³

2011

PIER

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Abstract-This study focuses on the evaluation of the performance of a rectangular waveguide for deep hyperthermia when different antennas are used. Although there are several models of hyperthermia applicators, there are no studies of the advantages of employing different antennas for waveguides used in deep seated tumor treatments. Monopole antennas are the most used radiating elements inside waveguides. Here, the modeling of a monopole and two new proposed antennas, inverted T and plate, in order to find their optimal performance is presented. Parameters like output power, SWR and transmission coefficient generated for each modeled antenna were calculated by using the finite element method. The antennas with the best performance were selected in order to model an applicator-phantom system, which was used to calculate the temperature distributions generated inside the muscle phantom. The models were based on Maxwell and bioheat equations. Finally, thermal distributions were obtained and compared. The results indicate that the plate antenna generated a better focusing. The SWR obtained was 1.25, the output power was 54.71 W of 66 W applied, and the 42 • C isotherm had a size of 2 cm × 2 cm.

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Section: Rectangular Waveguide Design Theory and Aperture Reductionmentioning

confidence: 99%

Fem Modeling for Performance Evaluation of an Electromagnetic Oncology Deep Hyperthermia Applicator When Using Monopole, Inverted T, and Plate Antennas

Trujillo-Romero¹,

Salas²,

Vera³

2011

PIER

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“…Therefore, if we place the metamaterial structures with relative permeability equal to −1 between a RF magnetic field source and a receiving device, the structure will focus the magnetic field from the source towards the receiver. This mechanism can be applied to improve the efficiency of energy transmission due to the fact that the radiation loss is reduced by focusing the magnetic field radiated outside the space between the source and the receiver in the wireless energy transmission system [5][6][7][8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

High-Efficiency Wireless Energy Transmission Using Magnetic Resonance Based on Negative Refractive Index Metamaterial

Choi¹,

Seo²

2010

PIER

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Abstract-In this paper, a high-efficiency wireless energy transmission via magnetic resonance is implemented by using negative permeability metamaterial structures. The metamaterial structure is consisted of a three-dimensional (3D) periodic array of the unit cell that the capacitively loaded split ring resonators (CLSRRs) are periodically arranged in the cubic dielectric surfaces. This metamaterial structure has the negative permeability property that matches free space, which is used as a magnetic flux guide in order to enhance the efficiency of energy transmission between a source and distant receiving coil. The efficiency of energy transmission is improved as reducing the radiation loss by focusing the magnetic field to a distant receiving coil. The distance able to transport the energy with maintaining the same efficiency has been increased by the same mechanism. The efficiency of energy transmission is approximately 80% at a transmission distance of 1.5 m.

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“…This paper reports the heating effects in a tissue-mimicking phantom. In this study, ferrofluid and MLs were used as MNPs to focus EM energy in tumors [25]. The temperature recorded during treatment increased, although not in a linear way, with the increase of the concentration of MNPs into the sphere.…”

Section: Discussionmentioning

confidence: 99%

Improved Thermal Ablation Efficacy Using Magnetic Nanoparticles: A Study in Tumor Phantoms

García-Jimeno¹,

Ortega-Palacios²,

Rubio³

et al. 2012

PIER

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Abstract-Magnetic heating used for inducing hyperthermia and thermal ablation is particularly promising in the treatment of cancer provided that the therapeutic temperature is kept constant during the treatment time throughout the targeted tissue and the healthy surrounding tissues are maintained at a safe temperature. The present study shows the temperature increment produced by different concentrations of magnetic nanoparticles (ferrofluid and magnetoliposomes) inside a phantom, after irradiating tissuemimicking materials (phantoms)with a minimally invasive coaxial antenna working at a frequency of 2.45 GHz. This frequency was chosen because maximum dielectric loss of water molecules begins at 2.4 GHz and because this is an ISM (industrial, scientific and medical) frequency. Temperature sensors were placed inside and outside the tumor phantom to assess the focusing effect of heat produced by nanoparticles. Results have shown that the temperature increments depend on the nanoparticles concentration. In this way, a temperature increment of more than 56 • C was obtained with a ferrofluid concentration of 13.2 mg/mL, whereas the increment in the reference phantom was only of ≈ 21 • C. Concerning the magnetoliposomes, the temperature achieved was similar to that obtained with the ferrofluid but at a lesser concentration of nanoparticles. These results

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Optimal Constrained Field Focusing for Hyperthermia Cancer Therapy: A Feasibility Assessment on Realistic Phantoms

Cited by 53 publications

References 30 publications

Fem Modeling for Performance Evaluation of an Electromagnetic Oncology Deep Hyperthermia Applicator When Using Monopole, Inverted T, and Plate Antennas

Fem Modeling for Performance Evaluation of an Electromagnetic Oncology Deep Hyperthermia Applicator When Using Monopole, Inverted T, and Plate Antennas

High-Efficiency Wireless Energy Transmission Using Magnetic Resonance Based on Negative Refractive Index Metamaterial

Improved Thermal Ablation Efficacy Using Magnetic Nanoparticles: A Study in Tumor Phantoms

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