Optimal concentration of light in turbid materials

Putten, E.G. van; Mosk, Allard

doi:10.1109/cleoe-eqec.2009.5192057

Cited by 8 publications

(10 citation statements)

References 34 publications

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“…The ability to manipulate light and to measure the TM of a sample has proven instrumental for fundamental scattering research [33,39,43]. In addition, wavefront shaping can be used for generating arbitrary spatio-temporal modes [70], high-resolution focusing [21,22,100], or for concentrating light inside nanoscale objects or plasmonic structures [101][102][103]. In addition, by shaping the incident light, disordered scattering materials can be 'programmed' to perform a large variety of optical functions, including beam splitters [104], spectrometers [105], polarization optics [65,66], and even single-photon wavefront generators [106].…”

Section: Applications and Outlookmentioning

confidence: 99%

Feedback-based wavefront shaping

Vellekoop¹

2015

Opt. Express

348

260

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Light scattering was thought to be the fundamental limitation for the depth at which optical imaging methods can retain their resolution and sensitivity. However, it was shown that light can be focused inside even the most strongly scattering objects by spatially shaping the wavefront of the incident light. This review summarizes recently developed feedback-based approaches for focusing light inside and through scattering objects.

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Section: Applications and Outlookmentioning

confidence: 99%

Feedback-based wavefront shaping

Vellekoop¹

2015

Opt. Express

348

260

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“…However, focusing with conventional lenses is restricted to one transport mean free path 6 in scattering media, limiting both optical penetration depth and resolution. Focusing deeper is possible by using optical phase conjugation 7-12 or wavefront shaping [13][14][15] to compensate for the scattering. For practical applications, wavefront shaping offers the advantage of a robust optical system that is less sensitive to optical misalignment.…”

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confidence: 99%

Ultrasonically encoded wavefront shaping for focusing into random media

Tay

Lai

Suzuki

et al. 2014

Sci Rep

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Phase distortions due to scattering in random media restrict optical focusing beyond one transport mean free path. However, scattering can be compensated for by applying a correction to the illumination wavefront using spatial light modulators. One method of obtaining the wavefront correction is by iterative determination using an optimization algorithm. In the past, obtaining a feedback signal required either direct optical access to the target region, or invasive embedding of molecular probes within the random media. Here, we propose using ultrasonically encoded light as feedback to guide the optimization dynamically and non-invasively. In our proof-of-principle demonstration, diffuse light was refocused to the ultrasound focal zone, with a focus-to-background ratio of more than one order of magnitude after 600 iterations. With further improvements, especially in optimization speed, the proposed method should find broad applications in deep tissue optical imaging and therapy.

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“…In related studies, researchers attempted to utilize the°uorescent microspheres as target guidestar, and to enhance the energy at these locations by optimizing and enhancing the outside detected°uorescent signal intensity. [64][65][66] However, the°uorescent microsphere guidestar is more used for theory and feasibility validations than in practical applications due to that it is embedded into the media, neither scannable nor moveable. Similar to the guidestars used in the OPC technology (those based on optic-acoustic interactions), the optoacoustic e®ect is rapidly introduced into the iterative waveform optimization as a type of noninvasive and scannable guidestar.…”

Section: Feedback-based Iterative Wavefront Optimization Approachesmentioning

confidence: 99%

Fast optical wavefront engineering for controlling light propagation in dynamic turbid media

Xia

Wang

2019

J. Innov. Opt. Health Sci.

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While propagating inside the strongly scattering biological tissue, photons lose their incident directions beyond one transport mean free path (TMFP, [Formula: see text]1 millimeter (mm)), which makes it challenging to achieve optical focusing or clear imaging deep inside tissue. By manipulating many degrees of the incident optical wavefront, the latest optical wavefront engineering (WFE) technology compensates the wavefront distortions caused by the scattering media and thus is toward breaking this physical limit, bringing bright perspective to many applications deep inside tissue, e.g., high resolution functional/molecular imaging, optical excitation (optogenetics) and optical tweezers. However, inside the dynamic turbid media such as the biological tissue, the wavefront distortion is a fast and continuously changing process whose decorrelation rate is on timescales from milliseconds (ms) to microseconds ([Formula: see text]s), or even faster. This requires that the WFE technology should be capable of beating this rapid process. In this review, we discuss the major challenges faced by the WFE technology due to the fast decorrelation of dynamic turbid media such as living tissue when achieving light focusing/imaging and summarize the research progress achieved to date to overcome these challenges.

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Optimal concentration of light in turbid materials

Cited by 8 publications

References 34 publications

Feedback-based wavefront shaping

Feedback-based wavefront shaping

Ultrasonically encoded wavefront shaping for focusing into random media

Fast optical wavefront engineering for controlling light propagation in dynamic turbid media

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